Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3662679..3663312 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag JR349_RS17170 Protein ID WP_003403365.1
Coordinates 3662929..3663312 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag JR349_RS17165 Protein ID WP_003403368.1
Coordinates 3662679..3662834 (+) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS17135 3657796..3660159 - 2364 WP_003901895.1 arylsulfatase AtsD -
JR349_RS17140 3660273..3660527 + 255 WP_003911263.1 antitoxin VapB7 -
JR349_RS17145 3660524..3660961 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
JR349_RS17150 3661071..3661316 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
JR349_RS17155 3661303..3661611 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
JR349_RS17160 3661887..3662603 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
JR349_RS17165 3662679..3662834 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JR349_RS17170 3662929..3663312 + 384 WP_003403365.1 ribonuclease VapC6 Toxin
JR349_RS17175 3663700..3664710 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
JR349_RS17180 3664791..3666296 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -
JR349_RS17185 3666367..3667062 + 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
JR349_RS17190 3667055..3667447 - 393 WP_003403353.1 50S ribosomal protein L7/L12 -
JR349_RS17195 3667484..3668020 - 537 WP_003403341.1 50S ribosomal protein L10 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T193890 WP_003403365.1 NZ_CP070338:3662929-3663312 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T193890 NZ_CP093260:c2479765-2479355 [Moellerella wisconsensis]
GTGGTCCTGTGGAAATCTAATTTATCCATATCATGGATGGCTCAGCTTTTTTCTACCTGTGTACATTGTGTCCTGGGGCT
AGTGTTATTACTGGCTCCGTGGCCGACAGGTAACTCTATTATTTGGCTTCCTTTATTAATGGTGACTATTGCGAGTTGGG
CAAAAAGTCAAAAAAACATTAATAAATACAAAGGAATAATTGTTCTTACTAATGGGAATAAAGTCCAATGGAAGAAAAAT
GAATGGAGTATTATCACTCCTCCATGGTGTACTCGCTTTGGTATTTTATTAACGTTAAGTGCATTACAAGGTAAACCTAG
AAAAATAAAATTATGGATTGCAGCTGATGCAATATCAGAAGACGATTGGCGAAATTTAAATCAGTTATTATTACAATATC
CTGATATATAA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT193890 WP_003403368.1 NZ_CP070338:3662679-3662834 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT193890 NZ_CP093260:c2480012-2479746 [Moellerella wisconsensis]
ATGGATATTGATAATAAAGCGCGGATCCACTGGGCATGTCGTCGAGGAATGCGAGAACTAGATATTTCAATCATGCCTTT
TTTTGAACATGAGTATGATGGATTAAACGATAATGAAAAACACCAGTTTATTCGTTTGCTGGAGTGTGCAGATCCCGATC
TGTTCAATTGGTTGATGAACCATGGTCGTCCTGACGATGATGAGCTTTATCATATGATTAAACTAATTCAACAAAGAAAT
AAAGACCGTGGTCCTGTGGAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References