Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 3660524..3661316 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag JR349_RS17145 Protein ID WP_003403386.1
Coordinates 3660524..3660961 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag JR349_RS17150 Protein ID WP_003403381.1
Coordinates 3661071..3661316 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS17120 3656987..3657160 - 174 WP_003898549.1 hypothetical protein -
JR349_RS17125 3657157..3657495 - 339 WP_003403405.1 PIN domain-containing protein -
JR349_RS17130 3657407..3657733 - 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JR349_RS17135 3657796..3660159 - 2364 WP_003901895.1 arylsulfatase AtsD -
JR349_RS17140 3660273..3660527 + 255 WP_003911263.1 antitoxin VapB7 -
JR349_RS17145 3660524..3660961 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
JR349_RS17150 3661071..3661316 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
JR349_RS17155 3661303..3661611 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
JR349_RS17160 3661887..3662603 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
JR349_RS17165 3662679..3662834 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
JR349_RS17170 3662929..3663312 + 384 WP_003403365.1 ribonuclease VapC6 -
JR349_RS17175 3663700..3664710 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
JR349_RS17180 3664791..3666296 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T193888 WP_003403386.1 NZ_CP070338:3660524-3660961 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T193888 NZ_CP093256:c267932-267543 [Moellerella wisconsensis]
GTGGCGTTCTATAAAATCTCATCTTTTGTCCGAAGCACCAAAAAAATACCTATAACAGACAAACAGTTACTTGATGCTGC
TCATGAAGTTCAACAAGGACAATTTGAAGCTGATTTAGGCGGTGGAGTGATAAAAAAACGCCTTGCAATGAAAGGGCAAG
GCAAAAGTGGAAGTGTTAGGGTTATTATCTTTTTTAAGATAAACAATCATCTTTTTTTTGCAGATGGATGGACCAAAAAC
ACGGTCAATGCCAAAGGTACAAAAGAGATTGAAGATGATGAGTTGGAAACCTATAAAAAATTAGCCGCTGAGTTTCTGAA
CTTTGATGGAGAAATCATTAACAATTTAATTTCTAAAGGAATTCTGGAGGAAATTACTGATGAACAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT193888 WP_003403381.1 NZ_CP070338:3661071-3661316 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT193888 NZ_CP093256:c267553-267224 [Moellerella wisconsensis]
ATGAACAATAAACTTAATAACATGCTTGAATTGGCTAAAGAGTTAAATGCAGCTGGTGCATCACCTGAAAGCCTGGTTAA
AGATATTGAAAGCACCATCCGTGCTCGTGAAATTAACGATAAAATAAAAGAAGTTTCAGCGATGAGCGGCTCTGAGATCA
AGATGTTGCGGACTAAATATTGTATGTCTCAATCTGTGCTCGCTCGTGCATTGGGAATGTCGAAAGAGAGCATATCCAAA
TGGGAGCGAGGAGAAAAGAAACCAAGCGGCCCTGCATTGAGGATGCTACGTATTCTTGAAAGCAAAGGCCCAGAAGTTTT
AGTGGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References