Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3574659..3575368 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag JR349_RS16675 Protein ID WP_003403837.1
Coordinates 3574659..3575087 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag JR349_RS16680 Protein ID WP_003403834.1
Coordinates 3575111..3575368 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS16650 3570362..3571894 + 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
JR349_RS16655 3571901..3573073 + 1173 WP_003403845.1 acyl-CoA dehydrogenase FadE9 -
JR349_RS16660 3573084..3573968 + 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
JR349_RS16665 3574037..3574282 - 246 WP_003403841.1 hypothetical protein -
JR349_RS16670 3574395..3574569 + 175 Protein_3293 transposase -
JR349_RS16675 3574659..3575087 - 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
JR349_RS16680 3575111..3575368 - 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
JR349_RS16685 3575459..3577732 - 2274 WP_016330384.1 PE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T193886 WP_003403837.1 NZ_CP070338:c3575087-3574659 [Mycobacterium tuberculosis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

>T193886 NZ_CP093256:72520-72852 [Moellerella wisconsensis]
ATGGTATCTCGATACGTTCCTGATTCTGGCGATTTGATTTGGATTGACTTTGATCCAGTTGAAGGACATGAGCAGGGCGG
TCATCGTCCAGCAGTTGTCCTCAGCCCATTTGCATACAATAATAAAGTAGGGCTCCTATTATGCGTACCATGTACAACTA
AGGGCAAAGGCTATCCATTTGAATGCGAACTCTCGAACGAAAGAGACAGCTACGCATTAGCGGATCAAGTTACATGTGTT
GACTGGAGAGCTCGTAAGGTTACTAAAAAGGGCAAAGTGGAGGCATCAGAACTGGCAGAGATAAAAGCTAAAGCAAAGGC
GTTAATAGGTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT193886 WP_003403834.1 NZ_CP070338:c3575368-3575111 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT193886 NZ_CP093256:72275-72520 [Moellerella wisconsensis]
ATGGCTCAGGTTACAGTAAAAAAATGGGGCAATAGCCCGTCAGTGCGACTTCCTGTTGCAATCATGCAAAAAGCGGCACT
TAGCGTTGATGATACGGTTGAAATAGCGGTAGAAGAAGGTCGTATAATCATTACGCCAGTTAAAGCGGTAGAATACTCAT
TAGAAAATTTGTTAGCCGGTATCACACCGGAGAATATTCATGAGAAAGTAGACTTCGGAGCTCGAACAGGTAAGGAATTA
ATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References