Detailed information of TA system TA193885

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 3401295..3401914
• Replicon: chromosome
• Accession: NZ_CP070338
• Organism: Mycobacterium tuberculosis strain 11502

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: JR349_RS15830
• Protein ID: WP_003404726.1
• Coordinates: 3401295..3401729 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: P9WJ06
• Locus tag: JR349_RS15835
• Protein ID: WP_003898641.1
• Coordinates: 3401735..3401914 (-)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JR349_RS15805	3396630..3397868	+	1239	WP_003404744.1	acetyl-CoA acetyltransferase	-
JR349_RS15810	3397870..3399378	+	1509	WP_003404742.1	carotenoid oxygenase family protein	-
JR349_RS15815	3399545..3399775	+	231	WP_003898642.1	hypothetical protein	-
JR349_RS15820	3399910..3400359	-	450	WP_003404738.1	hypothetical protein	-
JR349_RS15825	3400424..3401197	-	774	WP_003404735.1	VOC family protein	-
JR349_RS15830	3401295..3401729	-	435	WP_003404726.1	SRPBCC family protein	Toxin
JR349_RS15835	3401735..3401914	-	180	WP_003898641.1	antitoxin	Antitoxin
JR349_RS15840	3402040..3402198	-	159	WP_003404720.1	hypothetical protein	-
JR349_RS15845	3402471..3404864	-	2394	WP_003898639.1	cation-translocating P-type ATPase	-
JR349_RS15850	3404861..3406441	-	1581	WP_003910977.1	serine hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-50)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15754.47 Da
• Isoelectric Point: 9.7977

>T193885 WP_003404726.1 NZ_CP070338:c3401729-3401295 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Nucleotide

• Length: 435 bp

>T193885 NZ_CP093255:c3216341-3216075 [Moellerella wisconsensis]
TTGGTCTGGACGATTAATTATTCTGAACGGGCGTTAAAATCTTTACGAAAAATGGATAAACAGAGTGCTCGCCGTATTGT
CGATTTTATGGGTTTACGCATTGCAGCTTTAGATGATCCCCGACAGTTAGGCAAATCACTCAAAGGTGAACTAGGTGAGT
TCTGGCGTTATAGAGTTGGTGACTATCGGATACTATGCGAGATAAGGGATGATGAACTTGTCATTTTGGCTGCTACAACA
GGACATCGTCGTGAGATATATGAGTAA

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6403.07 Da
• Isoelectric Point: 4.5393

>AT193885 WP_003898641.1 NZ_CP070338:c3401914-3401735 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Nucleotide

• Length: 180 bp

>AT193885 NZ_CP093255:c3216549-3216325 [Moellerella wisconsensis]
ATGTTAGCTATTCGTTTATCTGATGACATTGAAACACGTCTGGAGTCACTTGCAAAACAGACAGGAAGAACCAAAACGTT
CTATGCGAGAGAAGCTATTCTCACCCACTTGGAAGACTTGGAAGACTACTATTTATCCGCTGAAACCATTGCAAAAATTC
GTAGCGGTGAAGAGTTGATTCATTCGTCTGAAGAGGTGAGAAAAACACTTGGTCTGGACGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A045KDK5