Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 2907737..2908341 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag JR349_RS13615 Protein ID WP_003414492.1
Coordinates 2907737..2908129 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag JR349_RS13620 Protein ID WP_003414495.1
Coordinates 2908126..2908341 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS13585 2902887..2903675 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
JR349_RS13590 2904009..2904554 - 546 WP_014584866.1 DUF1802 family protein -
JR349_RS13595 2904826..2905710 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
JR349_RS13600 2905713..2906600 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
JR349_RS13605 2906905..2907450 - 546 WP_003910939.1 DUF1802 family protein -
JR349_RS13610 2907447..2907716 - 270 WP_003414489.1 DUF2277 family protein -
JR349_RS13615 2907737..2908129 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
JR349_RS13620 2908126..2908341 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JR349_RS13625 2908388..2909137 + 750 WP_003902358.1 enoyl-CoA hydratase -
JR349_RS13630 2909216..2910298 - 1083 WP_003414499.1 ABC transporter ATP-binding protein -
JR349_RS13635 2910291..2911601 - 1311 WP_003414501.1 ABC transporter substrate-binding protein -
JR349_RS13640 2911604..2912431 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
JR349_RS13645 2912428..2913339 - 912 WP_003414505.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T193879 WP_003414492.1 NZ_CP070338:c2908129-2907737 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T193879 NZ_CP093250:c53893-53582 [Moellerella wisconsensis]
ATGCACGTAATTTCAAGAGATCCTTTTAACCAGGCATCCAAGCGATTTCCTAACAGTGCTCAGGCGTTATCTGACGTATA
TCGAACACTTAAGCGCGATAGTTATCAGACACCCGATGAGCTTAAGAAGGTTTTCCCCAGCCTTGACCGAATGAAGTACA
GAGAGAAATGGTGGGTTATCGATATCAGTGGAAATGCGTTAAGAATGATGTTTTTCGCCGACTTTGACCGGGGAAAAATA
TTCGTGAAACACATAACGACCCACGCAGAGTACGATAAGTTGACAGATCACTACCGGAGAACAAAAGCATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT193879 WP_003414495.1 NZ_CP070338:c2908341-2908126 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT193879 NZ_CP093250:c53585-53169 [Moellerella wisconsensis]
ATGATGTTTCAAGACGCCGTAAAAGCGGCACAAAACCTGGTAAATCTAGTCCCGTTACTGGGAGACAGCCATTCACGCCC
GGATTATGAAAAGGCCGTTCAGTTGGTGGAGCATCTTGTCGAGAACGACCCTGACAATCCGCTCATCGATATGATTTGCG
CAAAAATAGATGCGTATGAAAATGCCGCACCTGAATTTGCAGAGTTTAACCAACGTTTAGCAGAAAGTAATGATGGTGTG
GCAGCGTTAAGAACGCTGATGGATCAATACAACCTCAATACGACAGACTTTGGAAATGAGCTCGGTTCTCGTTCATACGT
CAGCCGTATCCTCAATGGGGAACGTGGATTAACCTTGGAGCACATCAAAAATCTGTCCAAACGCTTTGGTATTCCAGCCT
CAATATTTATTCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References