Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2887539..2888109 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag JR349_RS13490 Protein ID WP_003414166.1
Coordinates 2887539..2887895 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag JR349_RS13495 Protein ID WP_003901465.1
Coordinates 2887879..2888109 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS13470 2882991..2884679 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
JR349_RS13475 2884683..2885009 - 327 WP_003414157.1 hypothetical protein -
JR349_RS13480 2885182..2885769 + 588 WP_003914429.1 DUF3558 family protein -
JR349_RS13485 2885788..2887437 + 1650 Protein_2667 CocE/NonD family hydrolase -
JR349_RS13490 2887539..2887895 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
JR349_RS13495 2887879..2888109 - 231 WP_003901465.1 antitoxin MazE Antitoxin
JR349_RS13500 2888152..2889195 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
JR349_RS13505 2889386..2889661 + 276 WP_003911993.1 DUF1778 domain-containing protein -
JR349_RS13510 2889837..2890091 - 255 WP_003917684.1 hypothetical protein -
JR349_RS13515 2890239..2890643 + 405 WP_003414181.1 hypothetical protein -
JR349_RS13520 2890640..2890831 + 192 WP_003414184.1 hypothetical protein -
JR349_RS13525 2890895..2892184 + 1290 Protein_2675 transposase family protein -
JR349_RS13530 2892418..2892675 + 258 WP_003899489.1 hypothetical protein -
JR349_RS13535 2892780..2893091 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T193877 WP_003414166.1 NZ_CP070338:c2887895-2887539 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T193877 NZ_CP093249:c3195784-3195518 [Moellerella wisconsensis]
TTGGTCTGGACGATTAATTATTCTGAACGGGCGTTAAAATCTCTACGAAAAATGGATAAACAGAGTGCTCGCCGTATTGT
CGATTTTATGGGTTTACGCATTGCAGCTTTAGATGATCCCCGACAGTTAGGCAAATCACTCAAAGGTGAACTAGGTGAGT
TCTGGCGTTATAGAGTTGGTGACTATCGGATACTATGCGAGATAAGGGATGATGAACTTGTCATTTTGGCTGCTACAACA
GGACATCGTCGTGAGATATATGAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT193877 WP_003901465.1 NZ_CP070338:c2888109-2887879 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT193877 NZ_CP093249:c3195992-3195768 [Moellerella wisconsensis]
ATGTTAGCTATTCGTTTATCTGATGACATTGAAACACGTCTGGAGTCACTTGCAAAACAGACAGGAAGAACCAAAACGTT
CTATGCGAGAGAAGCTATTCTCACCCACTTGGAAGACTTGGAAGACTACTATTTATCCGCTGAAACCATTGCAAAAATTC
GTAGCGGTGAAGAGTTGATTCATTCGTCTGAAGAGGTGAGAAAAACACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References