Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2707193..2707907 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag JR349_RS12440 Protein ID WP_003413460.1
Coordinates 2707467..2707907 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag JR349_RS12435 Protein ID WP_003413456.1
Coordinates 2707193..2707480 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS12400 2702615..2702860 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JR349_RS12405 2702857..2703261 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
JR349_RS12410 2703478..2704098 + 621 WP_003413441.1 DUF4178 domain-containing protein -
JR349_RS12415 2704109..2704603 + 495 WP_003413444.1 DUF2617 family protein -
JR349_RS12420 2704600..2705031 + 432 WP_003899390.1 DUF4247 domain-containing protein -
JR349_RS12425 2705056..2705514 + 459 WP_003413451.1 DUF350 domain-containing protein -
JR349_RS12430 2705511..2707082 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
JR349_RS12435 2707193..2707480 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
JR349_RS12440 2707467..2707907 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
JR349_RS12445 2707928..2708683 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
JR349_RS12450 2708816..2709412 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
JR349_RS12455 2709420..2710265 - 846 WP_003413466.1 acyl-CoA thioesterase II -
JR349_RS12460 2710294..2711193 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
JR349_RS12465 2711321..2711995 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T193874 WP_003413460.1 NZ_CP070338:2707467-2707907 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T193874 NZ_CP093249:2733067-2733318 [Moellerella wisconsensis]
ATGAAAGCGGTAAGCTACAGTGAAGCCAGACAGAATTTATCAACAACAATGATTCAAACAGTTGAAGATAGAGTACCTGT
ACTGATCACGCGCCAGAATGGCGAATCATGTGTACTGATGTCTCTCGATGAATATAACTCTCTCGAAGAGACGGCATACC
TAATGAGATCACCAAAAAATGCACGCAGACTTATGGACTCGATAGAAAGCCTAAAAGATGGAAAAGGGATGGAAAGGGAA
ATTATTAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT193874 WP_003413456.1 NZ_CP070338:2707193-2707480 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT193874 NZ_CP093249:2733315-2733569 [Moellerella wisconsensis]
GTGAAGCTAACATGGTCTGCCGAAGCATGGGAAGATTACTTGTACTGGCAAGAAACGGACAGAAAAACCGTAAAAAAGAT
AAATGAGCTCATTAAGAATGCCAGTAGAACACCATTTGAAGGAAAAGGTAAACCTGAACCTCTGAAACACAATCTTGCTG
GGTTCTGGTCACGAAGAATTACGGCGGAACATCGATTAGTCTATGCCGTTAGTAATGATTCCTTGCTAATAGCATCATGT
CGTTATCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References