Detailed information of TA system TA193870

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2631392..2632032
• Replicon: chromosome
• Accession: NZ_CP070338
• Organism: Mycobacterium tuberculosis strain 11502

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: JR349_RS12070
• Protein ID: WP_003412970.1
• Coordinates: 2631392..2631811 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: JR349_RS12075
• Protein ID: WP_003412975.1
• Coordinates: 2631808..2632032 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JR349_RS12040	2626982..2627704	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
JR349_RS12045	2628221..2628443	+	223	Protein_2383	type II toxin-antitoxin system VapB family antitoxin	-
JR349_RS12050	2628440..2628841	+	402	WP_003412963.1	PIN domain-containing protein	-
JR349_RS12055	2628876..2629796	-	921	WP_003412965.1	restriction endonuclease	-
JR349_RS12060	2630137..2630382	-	246	WP_071854223.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
JR349_RS12065	2630441..2631391	+	951	WP_003911916.1	Lsr2 family protein	-
JR349_RS12070	2631392..2631811	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
JR349_RS12075	2631808..2632032	-	225	WP_003412975.1	antitoxin VapB39	Antitoxin
JR349_RS12080	2632063..2634906	-	2844	WP_003899363.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
JR349_RS12085	2634978..2635379	-	402	WP_003412981.1	hypothetical protein	-
JR349_RS12090	2635379..2635849	-	471	WP_003899364.1	transcription antitermination factor NusB	-
JR349_RS12095	2635852..2636415	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T193870 WP_003412970.1 NZ_CP070338:c2631811-2631392 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T193870 NZ_CP093246:22008-22358 [Moellerella wisconsensis]
ATGTGGGAAATATTAACGAGAGACCTCTTCGATTCATGGTTCGAAGAACAGAATGAGGAAACTCAAATTGAAGTGTTGGC
GGTGCTCATGATTTTACGTGAAGATGGCCCAAACCTTGGTCGGCCCCAGGTCGATACACTGAAAGGTTCGCAGTTTCCCA
ATATGAAGGAACTGCGAATTCAGGTTGGTGGTCATCCGATTAGAGCGTGTTTTGCATTTGACCCTATCCGCCGTGGCATT
GTGTTATGTGCTGGTGATAAGAAAGGAAAAGACGAAACGCGTTTCTATAAGAAGTTAATCAAGATGGCCGACGCTGAATA
CTCAGCGCATCTATTAGAGCAGGAGAAATAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT193870 WP_003412975.1 NZ_CP070338:c2632032-2631808 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT193870 NZ_CP093246:22360-22659 [Moellerella wisconsensis]
ATGTCCACTTTAAATGAACTACTTGCAAAACAATCCCCAGAGGCGTTGGCTAAAATTGAAGCGCGTGCGGAAGAGATCCG
TAGGGAAATAACGCTGGCTAAAATTCGTGAGGAACTCAATCTTTCCCAGTCAGAATTAGCCAAGTCCCTTGGCGTTTCAC
AACCCTCTATTGCCAAGCTTGAGAATGTTGATAACGATCCAAAGTTATCTACGTTGAAACGTTATATAAAAGCTTTAGGC
GGCGAGCTTTCTATTGATGTAACGCTACCGAATGGTAAGCGTATTGGATTGCATCTTTAA

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09