Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2182644..2183173 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag JR349_RS09995 Protein ID WP_003411124.1
Coordinates 2182644..2182961 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag JR349_RS10000 Protein ID WP_003411127.1
Coordinates 2182958..2183173 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS09965 2177665..2178741 + 1077 WP_003411110.1 hypothetical protein -
JR349_RS09970 2178738..2179019 + 282 WP_003411112.1 hypothetical protein -
JR349_RS09975 2179055..2180128 + 1074 WP_003901338.1 quinone-dependent dihydroorotate dehydrogenase -
JR349_RS09980 2180133..2180663 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
JR349_RS09985 2180711..2182057 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
JR349_RS09995 2182644..2182961 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JR349_RS10000 2182958..2183173 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
JR349_RS10005 2183428..2184486 + 1059 WP_003411129.1 hypothetical protein -
JR349_RS10010 2184616..2184972 - 357 WP_003411130.1 hypothetical protein -
JR349_RS10015 2185067..2185849 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
JR349_RS10020 2186117..2186407 - 291 WP_003900476.1 YggT family protein -
JR349_RS10025 2186569..2187225 - 657 WP_003411133.1 cell division protein SepF -
JR349_RS10030 2187287..2188066 - 780 WP_015575160.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T193868 WP_003411124.1 NZ_CP070338:c2182961-2182644 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T193868 NZ_CP093245:2899264-2899488 [Moellerella wisconsensis]
ATGAATGAAAGACAGGAAAATATGACTAAAACAGACTATCTGATGCGTTTAAGAAAATGCACGACTATTGAAACATTAGA
GCGTGTTATTGAAAAAAATAAATATGAGCTATCTGATGATGAACTCGAACTGTTTTTTTCCGCTGCTGACCATCGTCTAG
CAGAACTAACAATGAATAAACTGTATGACAAAATTCCAGCATCTGTCTGGAAATATGTTCGATAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT193868 WP_003411127.1 NZ_CP070338:c2183173-2182958 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT193868 NZ_CP093245:2898849-2899217 [Moellerella wisconsensis]
ATGGATGAATATTCACCCAGATATTACGATACTGCTGAATTAAAGTATTTATGTGATAGCCTTAACAATGATGCGATATT
ATCGCTACATAAGACTAAAACGCATTGGATTAATGATTTAAGTTCACAGCAAAGTACGAATTTGAATGAGTTAATAGAGC
ATGTGGCTGCATTTTTTTGGAAATTTAAGATAAAATACCCTAGTGAACGCTTAGTCATCTCTCTAGTTGATGAATATCTT
GATGAAACTTATAATTTATTTGGTAGTCCATTAATCACATTAAATGAATTTTCAGATTGGCAAAAAATGAATACTCACTT
AATTGATGAATTAAATAACGATTTAAAGTGTTCAGTAGCCAAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References