Detailed information of TA system TA193867

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2143008..2143703
• Replicon: chromosome
• Accession: NZ_CP070338
• Organism: Mycobacterium tuberculosis strain 11502

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JR349_RS09785
• Protein ID: WP_003905754.1
• Coordinates: 2143008..2143442 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TMN0
• Locus tag: JR349_RS09790
• Protein ID: WP_003410814.1
• Coordinates: 2143449..2143703 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JR349_RS09775	2139162..2142203	+	3042	WP_003899171.1	DEAD/DEAH box helicase	-
JR349_RS09780	2142196..2143029	+	834	WP_003899172.1	SWIM zinc finger family protein	-
JR349_RS09785	2143008..2143442	-	435	WP_003905754.1	type II toxin-antitoxin system VapC family toxin	Toxin
JR349_RS09790	2143449..2143703	-	255	WP_003410814.1	antitoxin	Antitoxin
JR349_RS09795	2143719..2143976	-	258	WP_003410816.1	hypothetical protein	-
JR349_RS09800	2144510..2145771	+	1262	WP_087902221.1	IS3-like element IS987 family transposase	-
JR349_RS09810	2147639..2147935	+	297	WP_003410820.1	PE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15632.05 Da
• Isoelectric Point: 7.4681

>T193867 WP_003905754.1 NZ_CP070338:c2143442-2143008 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Nucleotide

• Length: 435 bp

>T193867 NZ_CP093245:2648999-2649253 [Moellerella wisconsensis]
GTGAAGCTAACATGGTCTGCCGAAGCATGGGAAGATTACTTGTACTGGCAAGAAACGGACAGAAAAACCGTAAAAAAGAT
AAATGAGCTCATTAAGAATGCCAGTAGAACACCATTTGAAGGAAAAGGTAAACCTGAACCTCTGAAACACAATCTTGCTG
GGTTCTGGTCACGAAGAATTACGGCGGAACATCGATTAGTCTATGCCGTTAGTAATGATTCCTTGCTAATAGCATCATGT
CGTTATCACTACTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9417.57 Da
• Isoelectric Point: 8.9912

>AT193867 WP_003410814.1 NZ_CP070338:c2143703-2143449 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Nucleotide

• Length: 255 bp

>AT193867 NZ_CP093245:2648751-2649002 [Moellerella wisconsensis]
ATGAAAGCGGTAAGCTACAGTGAAGCCAGACAGAATTTATCAACAACAATGATTCAAACAGTTGAAGATAGAGTACCAGT
ACTGATCACGCGCCAGAATGGCGAATCATGTGTACTGATGTCTCTCGATGAATATAACTCTCTCGAAGAGACGGCATACC
TAATGAGATCACCAAAAAATGCACGCAGACTTATGGACTCGATAGAAAGCCTAAAAGATGGAAAAGGGATGGAAAGGGAA
ATTATTAAGTGA

Structures

Antitoxin

• AlphaFold DB: G0TMN0