Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2003938..2004836 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag JR349_RS09165 Protein ID WP_003410001.1
Coordinates 2003938..2004498 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag JR349_RS09170 Protein ID WP_003410003.1
Coordinates 2004495..2004836 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS09135 1999107..1999760 - 654 WP_003409976.1 cutinase Cfp21 -
JR349_RS09140 1999875..2000105 + 231 WP_003409980.1 DUF167 domain-containing protein -
JR349_RS09145 2000190..2001101 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JR349_RS09150 2001210..2001809 + 600 WP_003910883.1 L-lysine exporter -
JR349_RS09155 2002225..2002653 + 429 WP_003409992.1 cellulose-binding protein -
JR349_RS09160 2002879..2003418 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
JR349_RS09165 2003938..2004498 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
JR349_RS09170 2004495..2004836 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
JR349_RS09175 2004922..2005179 + 258 WP_003410006.1 hypothetical protein -
JR349_RS09180 2005080..2005415 - 336 WP_003410009.1 dehydrogenase -
JR349_RS09185 2005504..2005848 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
JR349_RS09190 2005842..2006090 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
JR349_RS09195 2006190..2008505 - 2316 WP_003899120.1 cation transporter ATPase CptG -
JR349_RS09200 2008502..2008774 - 273 WP_003410017.1 DUF1490 family protein -
JR349_RS09205 2008827..2009183 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T193862 WP_003410001.1 NZ_CP070338:c2004498-2003938 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T193862 NZ_CP093243:c253729-253382 [Moellerella wisconsensis]
ATGGTATCTCGATACGTACCTGATTCTGGCGATTTGATTTGGATTGACTTTGATCCAGTTGAAGGACATGAGCAGGGCGG
TCATCGTCCAGCAGTTGTCCTTAGCCCTTTTGCATACAATAATAAAGTAGGGCTCTTACTATGCGTACCATGTACAACTA
AAGGCAAAGGCTATCCATTTGAATGCGAACTCTCGAACGAAAGAGACAGCTACGCATTAGCGGATCAAGTTACATGTGTT
GACTGGAGAGCTCGTAAAGTTACTAAAAAGGGCAAAGTGGAGGCATCAGAACTGGCAGAGATAAGGCGGATTCAAGTCCG
AAGTGCAACGCTAAGCCGCCTTTCTTAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT193862 WP_003410003.1 NZ_CP070338:c2004836-2004495 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT193862 NZ_CP093243:c253974-253729 [Moellerella wisconsensis]
ATGGCTCAGGTCACAGTAAAAAAATGGGGCAATAGCCCGTCTGTACGGCTTCCTGTTGCAATCATGCAAAAAGCGGCACT
TAGCGTTGATGATACGGTTGAAATAGCGGTAGAAGAAGGTCGTATCATCATTACGCCAGTTAAAGCGGTAGAATACTCAT
TAGATAATTTGTTAGCCGGTATCACACCGGAGAATATCCATGAGAAAGTAGACTTCGGAGCTCGAACAGGTAAGGAATTA
ATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References