Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1996612..1997300 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag JR349_RS09120 Protein ID WP_003409958.1
Coordinates 1996612..1997031 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag JR349_RS09125 Protein ID WP_003409968.1
Coordinates 1997040..1997300 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS09095 1992467..1992679 - 213 Protein_1803 class I SAM-dependent methyltransferase -
JR349_RS09100 1992683..1992955 + 273 Protein_1804 SAM-dependent methyltransferase -
JR349_RS09105 1992918..1994363 - 1446 WP_003899115.1 APC family permease -
JR349_RS09110 1994542..1995228 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
JR349_RS09115 1995419..1996387 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
JR349_RS09120 1996612..1997031 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
JR349_RS09125 1997040..1997300 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JR349_RS09130 1997443..1999119 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
JR349_RS09135 1999107..1999760 - 654 WP_003409976.1 cutinase Cfp21 -
JR349_RS09140 1999875..2000105 + 231 WP_003409980.1 DUF167 domain-containing protein -
JR349_RS09145 2000190..2001101 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JR349_RS09150 2001210..2001809 + 600 WP_003910883.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T193861 WP_003409958.1 NZ_CP070338:c1997031-1996612 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T193861 NZ_CP093243:c193611-193261 [Moellerella wisconsensis]
ATGTGGGAAATATTAACGAGAGACCTCTTCGATTCATGGTTCGAAGAACAGAATGAGGAAACTCAAATTGAAGTGTTGGC
GGTGCTCATGATTTTACGTGAAGATGGCCCAAACCTTGGTCGGCCCCAGGTCGATACACTGAAAGGTTCGCAGTTTCCCA
ATATGAAGGAACTGCGAATTCAGGTTGGTGGTCATCCGATTAGAGCGTGTTTTGCATTTGACCCTATCCGCCGTGGCATT
GTGTTATGTGCTGGTGATAAGAAAGGAAAAGACGAAACGCGTTTCTATAAGAAGTTAATCAAGATGGCCGACGCTGAATA
CTCAGCGCATCTATTAGAGCAGGAGAAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT193861 WP_003409968.1 NZ_CP070338:c1997300-1997040 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT193861 NZ_CP093243:c193259-192960 [Moellerella wisconsensis]
ATGTCCACTTTAAATGAACTACTTGCAAAACAATCCCCAGAGGCGTTGGCTAAAATTGAAGCGCGTGCGGAAGAGATCCG
TAGGGAAATAACGCTGGCTAAAATTCGTGAGGAACTCAATCTTTCCCAGTCAGAATTAGCCAAGTCCCTTGGCGTTTCAC
AACCCTCTATTGCCAAGCTTGAGAATGTTGATAACGATCCAAAGTTATCTACGTTGAAACGTTATATAAAAGCTTTAGGC
GGCGAGCTTTCTATTGATGTAACGCTACCGAATGGTAAGCGTATTGGATTGCATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References