Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1972140..1972684 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag JR349_RS08980 Protein ID WP_003409896.1
Coordinates 1972140..1972436 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag JR349_RS08985 Protein ID WP_003409899.1
Coordinates 1972433..1972684 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS08925 1967173..1967523 - 351 WP_003409871.1 hypothetical protein -
JR349_RS08930 1967534..1968436 - 903 WP_003899097.1 hypothetical protein -
JR349_RS08935 1968457..1968648 - 192 WP_003409876.1 hypothetical protein -
JR349_RS08940 1968649..1968945 - 297 WP_003409877.1 hypothetical protein -
JR349_RS08945 1969185..1969400 + 216 WP_003409878.1 antitoxin -
JR349_RS08950 1969397..1969708 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
JR349_RS08955 1969682..1970203 - 522 WP_003904745.1 hypothetical protein -
JR349_RS08960 1970178..1970555 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
JR349_RS08965 1970597..1971046 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
JR349_RS08970 1971043..1971588 + 546 WP_003409891.1 SecB-like chaperone -
JR349_RS08975 1971477..1972091 - 615 WP_003901296.1 hypothetical protein -
JR349_RS08980 1972140..1972436 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JR349_RS08985 1972433..1972684 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
JR349_RS08990 1972671..1973165 + 495 WP_003899099.1 hypothetical protein -
JR349_RS08995 1973325..1973732 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
JR349_RS09000 1973736..1974008 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JR349_RS09005 1974041..1975261 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
JR349_RS09010 1976160..1976957 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T193860 WP_003409896.1 NZ_CP070338:c1972436-1972140 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T193860 NZ_CP093243:c155528-155217 [Moellerella wisconsensis]
ATGCACGTAATTTCAAGAGATCCTTTTAACCAGGCATCCAAGCGATTTCCTAACAGTGCTCAGGCGTTATCTGACGTATA
TCGAACACTTAAGCGCGATAGTTATCAGACACCCGATGAGCTTAAGAAGGTTTTCCCCAGCCTTGACCGAATGAAGTACA
GAGAGAAATGGTGGGTTATCGATATCAGTGGAAATGCGTTAAGAATGATGTTTTTCGCCGACTTTGACCGGGGAAAAATA
TTCGTGAAACACATAACGACCCACGCAGAGTACGATAAGTTGACAGATCACTACCGGAGAACAAAAGCATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT193860 WP_003409899.1 NZ_CP070338:c1972684-1972433 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT193860 NZ_CP093243:c155220-154804 [Moellerella wisconsensis]
ATGATGTTTCAAGACGCCGTAAAAGCGGCACAAAACCTGGTAAATCTAGTCCCGTTACTGGGAGACAGCCATTCACGCCC
GGATTATGAAAAGGCCGTTCAGTTGGTGGAGCATCTTGTCGAGAACGACCCTGACAATCCGCTCATCGATATGATTTGCG
CAAAAATAGATGCGTATGAAAATGCCGCACCTGAATTTGCAGAGTTTAACCAACGTTTAGCAGAAAGTAATGATGGTGTG
GCAGCGTTAAGAACGCTGATGGATCAATACAACCTCAATACGACAGACTTTGGAAATGAGCTCGGTTCTCGTTCATACGT
CAGCCGTATCCTCAATGGGGAACGTGGATTAACCTTGGAGCACATCAAAAATCTGTCCAAACGCTTTGGTATTCCAGCCT
CAATATTTATTCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References