Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1743847..1744307 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag JR349_RS07920 Protein ID WP_003898996.1
Coordinates 1744059..1744307 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag JR349_RS07915 Protein ID WP_003408528.1
Coordinates 1743847..1744059 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS07900 1740325..1741512 - 1188 WP_003898992.1 nitrate transporter NarK -
JR349_RS07905 1741799..1742083 + 285 WP_003408522.1 DUF1876 domain-containing protein -
JR349_RS07910 1742097..1743779 - 1683 WP_003901239.1 SulP family inorganic anion transporter -
JR349_RS07915 1743847..1744059 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JR349_RS07920 1744059..1744307 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
JR349_RS07925 1744315..1745052 + 738 WP_003898997.1 hypothetical protein -
JR349_RS07930 1745146..1746846 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
JR349_RS07935 1747131..1747532 - 402 WP_003408538.1 hypothetical protein -
JR349_RS07940 1747522..1748133 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T193857 WP_003898996.1 NZ_CP070338:1744059-1744307 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T193857 NZ_CP093242:2921332-2921556 [Moellerella wisconsensis]
ATGAATGAAAGACAGGAAAATATGACTAAAACAGACTATCTGATGCGTTTAAGAAAATGCACGACTATTGAAACATTAGA
GCGTGTTATTGAAAAAAATAAATATGAGCTATCTGATGATGAACTCGAACTGTTTTTTTCCGCTGCTGACCATCGTCTAG
CAGAACTAACAATGAATAAACTGTATGACAAAATTCCAGCATCTGTCTGGAAATATGTTCGATAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT193857 WP_003408528.1 NZ_CP070338:1743847-1744059 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT193857 NZ_CP093242:2920917-2921285 [Moellerella wisconsensis]
ATGGATGAATATTCACCCAGATATTACGATACTGCTGAATTAAAGTATTTATGTGATAGCCTTAACAATGATGCGATATT
ATCGCTACATAAGACTAAAACGCATTGGATTAATGATTTAAGTTCACAGCAAAGTACGAATTTGAATGAGTTAATAGAGC
ATGTGGCTGCATTTTTTTGGAAATTTAAGATAAAATACCCTAGTGAACGCTTAGTCATCTCTCTAGTTGATGAATATCTT
GATGAAACTTATAATTTATTTGGTAGTCCATTAATCACATTAAATGAATTTTCAGATTGGCAAAAAATGAATACTCACTT
AATTGATGAATTAAATAACGATTTAAAGTGTTCAGTAGCCAAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References