Detailed information of TA system TA193856

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1723023..1723636
• Replicon: chromosome
• Accession: NZ_CP070338
• Organism: Mycobacterium tuberculosis strain 11502

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JR349_RS07805
• Protein ID: WP_003910864.1
• Coordinates: 1723023..1723412 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WJ52
• Locus tag: JR349_RS07810
• Protein ID: WP_003408469.1
• Coordinates: 1723409..1723636 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JR349_RS07775	1718652..1719566	+	915	WP_003898985.1	3-hydroxyacyl-CoA dehydrogenase family protein	-
JR349_RS07780	1719569..1720399	+	831	WP_003408448.1	cyclase family protein	-
JR349_RS07785	1720399..1720749	+	351	WP_003898986.1	cupin domain-containing protein	-
JR349_RS07790	1720802..1721620	+	819	WP_003408456.1	3-keto-5-aminohexanoate cleavage protein	-
JR349_RS07795	1721634..1722413	+	780	WP_003408460.1	IclR family transcriptional regulator	-
JR349_RS07805	1723023..1723412	-	390	WP_003910864.1	PIN domain-containing protein	Toxin
JR349_RS07810	1723409..1723636	-	228	WP_003408469.1	antitoxin	Antitoxin
JR349_RS07815	1723854..1725338	+	1485	WP_003408473.1	carboxylase	-
JR349_RS07820	1725335..1726582	+	1248	WP_003408476.1	serine hydrolase	-
JR349_RS07825	1726625..1727044	-	420	WP_003408483.1	hypothetical protein	-
JR349_RS07830	1727034..1727744	-	711	WP_003408486.1	winged helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (3-117)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 13837.02 Da
• Isoelectric Point: 7.4232

>T193856 WP_003910864.1 NZ_CP070338:c1723412-1723023 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVRAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Nucleotide

• Length: 390 bp

>T193856 NZ_CP093242:2712727-2712981 [Moellerella wisconsensis]
GTGAAGCTAACATGGTCTGCCGAAGCATGGGAAGATTACTTGTACTGGCAAGAAACGGACAGAAAAACCGTAAAAAAGAT
AAATGAGCTCATTAAGAATGCCAGTAGAACACCATTTGAAGGAAAAGGTAAACCTGAACCTCTGAAACACAATCTTGCTG
GGTTCTGGTCACGAAGAATTACGGCGGAACATCGATTAGTCTATGCCGTTAGTAATGATTCCTTGCTAATAGCATCATGT
CGTTATCACTACTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8226.39 Da
• Isoelectric Point: 4.3313

>AT193856 WP_003408469.1 NZ_CP070338:c1723636-1723409 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Nucleotide

• Length: 228 bp

>AT193856 NZ_CP093242:2712479-2712730 [Moellerella wisconsensis]
ATGAAAGCGGTAAGCTACAGTGAAGCCAGACAGAATTTATCAACAACAATGATTCAAACAGTTGAAGATAGAGTACCTGT
ACTGATCACGCGCCAGAATGGCGAATCATGTGTACTGATGTCTCTCGATGAATATAACTCTCTCGAAGAGACGGCATACC
TAATGAGATCACCAAAAAATGCACGCAGACTTATGGACTCGATAGAAAGCCTAAAAGATGGAAAAGGGATGGAAAGGGAA
ATTATTAAGTGA

Structures

Antitoxin

• PDB: 7E4J
• AlphaFold DB: A0A7U4FAN9