Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1354803..1355458 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag JR349_RS06190 Protein ID WP_003898861.1
Coordinates 1354803..1355204 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag JR349_RS06195 Protein ID WP_003407272.1
Coordinates 1355201..1355458 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS06175 1350275..1351660 - 1386 WP_003407260.1 cytochrome P450 -
JR349_RS06180 1351738..1352772 + 1035 WP_003407264.1 AraC family transcriptional regulator -
JR349_RS06185 1352818..1354548 - 1731 WP_009940170.1 PE family protein -
JR349_RS06190 1354803..1355204 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
JR349_RS06195 1355201..1355458 - 258 WP_003407272.1 ribbon-helix-helix domain-containing protein Antitoxin
JR349_RS06200 1355541..1356500 - 960 WP_003407276.1 alpha/beta hydrolase -
JR349_RS06205 1356525..1357487 - 963 WP_003905554.1 alpha/beta hydrolase -
JR349_RS06210 1357486..1358223 + 738 WP_031647000.1 lysoplasmalogenase -
JR349_RS06215 1358304..1360271 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T193853 WP_003898861.1 NZ_CP070338:c1355204-1354803 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T193853 NZ_CP093240:52029-52403 [Escherichia marmotae]
ATGATATTAGTAGATACGTCTGTGTGGGTTGATCATTTTAAAAATAAAAATGATACATTGATTCAGCTATTGCAGTCAGA
CTTTGTTCTTATGCACCCAATGATCCTGGCTGAAATTGCTTGTGGCACACCGCCAGCGCCCAGACAGCGAACATTGAGTG
ATTTAGACTTGTTACCGAAAAGTCATCAGGCCACGATTACTGAAGTTCTGGCGTTCATTGAAAATGAAAAATTATTCGGC
CTGGGCTGTGGTCTGGTTGATATAACATTATTAGCGTCAACGAGGATTACTCCCGGGGCTAAAATATGGACGCTGGATAA
ACGATTGTCACGACTGGCAAAACGCCTGAATGTAGAATATCAACCTGTACATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT193853 WP_003407272.1 NZ_CP070338:c1355458-1355201 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT193853 NZ_CP093240:51829-52032 [Escherichia marmotae]
ATGAGAACTACTGTAACGATCGACGATGCTCTGTACGCACAGGCGCTGGAAATGGCTGATCCAGGCATGGATAAATCAGA
TATTTTCCGTGAAGCTGTGAAAACGTTTATTCGTGTGCAGGCTGCGAAACGCCTGGCTTCACTTGGCGGAACAGCCCCGG
ATATGGAGATAACACCACGCAGGCGTGGAGATGTGGCGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References