Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1319082..1320132 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag JR349_RS06030 Protein ID WP_003407164.1
Coordinates 1319082..1319903 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag JR349_RS06035 Protein ID WP_003407167.1
Coordinates 1319896..1320132 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS06010 1314640..1315302 - 663 WP_003407152.1 membrane protein -
JR349_RS06015 1315299..1316084 - 786 WP_003407157.1 membrane protein -
JR349_RS06020 1316375..1318336 - 1962 WP_003407159.1 sigma-F factor regulator -
JR349_RS06025 1318475..1318861 - 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
JR349_RS06030 1319082..1319903 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
JR349_RS06035 1319896..1320132 + 237 WP_003407167.1 hypothetical protein Antitoxin
JR349_RS06040 1320204..1321409 - 1206 WP_003918234.1 serine hydrolase -
JR349_RS06045 1321712..1322497 + 786 WP_003902048.1 lipoprotein LprF -
JR349_RS06050 1322693..1323307 + 615 Protein_1196 cytochrome b5 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T193852 WP_003407164.1 NZ_CP070338:1319082-1319903 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

>T193852 NZ_CP093240:33057-33344 [Escherichia marmotae]
ATGACTTATACGGTCAAATTCAGGGATGATGCGCTGAAAGAGTGGCTGAAGCTGGATAAAGCCATTCAACAGCAATTTGC
GAAAAAGCTAAAGAAGTGCAGTGAAAATCCGCACATCCCTTCAGCAAAACTGCGAGGGATAAAGGACTGCTACAAAATCA
AGCTTCGAGCCTCTGGTTTTCGTCTGGTTTATCAGGTGATTGACGATCAATTAATTATCGCTGTTGTAGCTGTAGGAAAA
CGTGAACGTAGTGACGTTTATAATCTTGCCAGTGAGCGAATGAGATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT193852 WP_003407167.1 NZ_CP070338:1319896-1320132 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp

>AT193852 NZ_CP093240:32809-33060 [Escherichia marmotae]
ATGCCTAACATTATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATCCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTGGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References