Detailed information of TA system TA193851

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1167792..1168351
• Replicon: chromosome
• Accession: NZ_CP070338
• Organism: Mycobacterium tuberculosis strain 11502

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: JR349_RS05375
• Protein ID: WP_003898789.1
• Coordinates: 1167792..1168085 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: JR349_RS05380
• Protein ID: WP_003406322.1
• Coordinates: 1168082..1168351 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JR349_RS05350	1163490..1163750	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
JR349_RS05355	1163747..1164178	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
JR349_RS05360	1164201..1165784	-	1584	WP_009940130.1	PE family protein	-
JR349_RS05365	1165964..1166824	+	861	WP_003900301.1	hypothetical protein	-
JR349_RS05370	1166905..1167735	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
JR349_RS05375	1167792..1168085	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
JR349_RS05380	1168082..1168351	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JR349_RS05385	1168464..1172159	-	3696	WP_003406323.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
JR349_RS05390	1172301..1173089	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T193851 WP_003898789.1 NZ_CP070338:c1168085-1167792 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T193851 NZ_CP093239:c4148589-4148101 [Escherichia marmotae]
ATGATCTCCGCTCCTGAGCCGCTTCACGCCGGGCATATTCTTACCCCGTTTTGCTGTGGCGTGGATTCTATGGATAACTG
GCTGAAACAACGGGCGATGAAAAATCAGGTCACTGGCGCATCCCGTACTTTTGTATGTTGCGGCAGTGATTCTAAGGTAC
TGGCGTATTACTCGCTGGCATCCAGTGCAGTGATGACAAACACTGCCCCCGGCCGCTTTCGCCGTAATATGCCCGATCCG
ATCCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATCAGTCTATACATGGGCAGGGTGTTGGTCGGGCGCTGGTACGTGA
CGCCGGGCTGCGGGTGATTCAGGTGGCTGAAACTATCGGTATTCGCGGGATGCTGGTTCATGCGCTGTCTGATGAGGCGC
GGGATTTCTATCTGCGGGTGGGGTTTGAGCCGTCACCGATGGATCCGATGATGTTGCTGGTGACGTTGGGGGATTTGGTT
CATGCTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT193851 WP_003406322.1 NZ_CP070338:c1168351-1168082 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT193851 NZ_CP093239:c4148879-4148586 [Escherichia marmotae]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAATCTGCGCATCAGGCCCGCCGAGCGCGATCTTATCGA
TCGGGCTGCGAAAGCCAGAGGAAAAAACCGCACTGACTTTGTGCTGGAGGCTGCCCGCGCCGCGGCGGAAGAGGCGCTGA
TCGAGCAGCGTATCATTATGGCCGATCCGGAGGCTTATCAGACGTTTCTTACCCGCCTTGATCAGGCTCCAGCGCCAAAC
TCCGCGCTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2