Detailed information of TA system TA193850

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1163490..1164178
• Replicon: chromosome
• Accession: NZ_CP070338
• Organism: Mycobacterium tuberculosis strain 11502

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: JR349_RS05355
• Protein ID: WP_003406304.1
• Coordinates: 1163747..1164178 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: JR349_RS05350
• Protein ID: WP_003406302.1
• Coordinates: 1163490..1163750 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JR349_RS05330	1159067..1159891	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
JR349_RS05335	1159896..1161077	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
JR349_RS05340	1161154..1162254	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
JR349_RS05345	1162425..1163414	+	990	WP_003406301.1	malate dehydrogenase	-
JR349_RS05350	1163490..1163750	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
JR349_RS05355	1163747..1164178	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
JR349_RS05360	1164201..1165784	-	1584	WP_009940130.1	PE family protein	-
JR349_RS05365	1165964..1166824	+	861	WP_003900301.1	hypothetical protein	-
JR349_RS05370	1166905..1167735	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
JR349_RS05375	1167792..1168085	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
JR349_RS05380	1168082..1168351	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T193850 WP_003406304.1 NZ_CP070338:1163747-1164178 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T193850 NZ_CP093239:4143600-4143977 [Escherichia marmotae]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCACCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT193850 WP_003406302.1 NZ_CP070338:1163490-1163750 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT193850 NZ_CP093239:4143180-4143554 [Escherichia marmotae]
GTGTCAGACACACTCCATGAGACAACTCATCCCGACGACAATCGCGGCCGCCCCTGGTGGGGACTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTATGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTATATCCGACACTGGCACCCGCAACCACCTCATAA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6