Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 708996..709670 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag JR349_RS03215 Protein ID WP_003417282.1
Coordinates 709242..709670 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag JR349_RS03210 Protein ID WP_003417286.1
Coordinates 708996..709238 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS03185 705532..706596 + 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -
JR349_RS03190 706693..707067 + 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
JR349_RS03195 707064..707597 + 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
JR349_RS03200 707598..708263 + 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
JR349_RS03205 708260..708874 + 615 WP_003417288.1 class I SAM-dependent methyltransferase -
JR349_RS03210 708996..709238 + 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
JR349_RS03215 709242..709670 + 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
JR349_RS03220 709749..710540 - 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
JR349_RS03225 710540..712312 - 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
JR349_RS03230 712441..712875 - 435 WP_003902441.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
JR349_RS03235 712872..713306 - 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
JR349_RS03240 713447..713848 + 402 WP_003417264.1 cytidine deaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T193848 WP_003417282.1 NZ_CP070338:709242-709670 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T193848 NZ_CP093239:c2789666-2789511 [Escherichia marmotae]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATTGCGATGGCGCTGGTAATGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTTTTCGTAGACTACGAATCTAGAGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT193848 WP_003417286.1 NZ_CP070338:708996-709238 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT193848 NZ_CP093239:2789678-2789708 [Escherichia marmotae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References