Detailed information of TA system TA193839

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 361577..362103
• Replicon: chromosome
• Accession: NZ_CP070338
• Organism: Mycobacterium tuberculosis strain 11502

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: JR349_RS01575
• Protein ID: WP_003401560.1
• Coordinates: 361801..362103 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: P9WJ08
• Locus tag: JR349_RS01570
• Protein ID: WP_003401555.1
• Coordinates: 361577..361804 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JR349_RS01555	357270..358073	-	804	WP_003401540.1	hypothetical protein	-
JR349_RS01560	358083..359480	-	1398	WP_003401544.1	sulfatase	-
JR349_RS01565	359659..361434	+	1776	WP_010886074.1	PE family protein	-
JR349_RS01570	361577..361804	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	Antitoxin
JR349_RS01575	361801..362103	+	303	WP_003401560.1	toxin-antitoxin system toxin	Toxin
JR349_RS01580	362151..362372	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	-
JR349_RS01585	362369..362794	+	426	WP_003401566.1	PIN domain nuclease	-
JR349_RS01590	362930..363562	+	633	WP_003905275.1	TetR/AcrR family transcriptional regulator	-
JR349_RS01595	363559..364467	+	909	WP_031714300.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10442.16 Da
• Isoelectric Point: 4.9609

>T193839 WP_003401560.1 NZ_CP070338:361801-362103 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T193839 NZ_CP093239:c732690-732349 [Escherichia marmotae]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGAATTATAATCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTTGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACTCCCCGCCACCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTCGCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8130.21 Da
• Isoelectric Point: 7.0084

>AT193839 WP_003401555.1 NZ_CP070338:361577-361804 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Nucleotide

• Length: 228 bp

>AT193839 NZ_CP093239:732685-732761 [Escherichia marmotae]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin

• AlphaFold DB: A0A7U4F8T1