Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2544763..2545343 Replicon chromosome
Accession NZ_CP070327
Organism MAG: Ferrovum myxofaciens isolate MI1I

Toxin (Protein)


Gene name pemK Uniprot ID A0A859ACQ7
Locus tag JVY19_RS12720 Protein ID WP_031598903.1
Coordinates 2545017..2545343 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A8F3IGG2
Locus tag JVY19_RS12715 Protein ID WP_062188497.1
Coordinates 2544763..2545020 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JVY19_RS12685 (JVY19_12695) 2540396..2540725 + 330 WP_197456570.1 hypothetical protein -
JVY19_RS12690 (JVY19_12700) 2541338..2542798 + 1461 WP_273144676.1 IS21 family transposase -
JVY19_RS12695 (JVY19_12705) 2542801..2543547 + 747 WP_273144679.1 IS21-like element helper ATPase IstB -
JVY19_RS12700 (JVY19_12710) 2543537..2543809 + 273 WP_062188606.1 hypothetical protein -
JVY19_RS12705 (JVY19_12715) 2543992..2544288 + 297 WP_156472717.1 site-specific recombinase resolvase -
JVY19_RS12710 (JVY19_12720) 2544421..2544597 + 177 WP_156472716.1 hypothetical protein -
JVY19_RS12715 (JVY19_12725) 2544763..2545020 + 258 WP_062188497.1 hypothetical protein Antitoxin
JVY19_RS12720 (JVY19_12730) 2545017..2545343 + 327 WP_031598903.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JVY19_RS12725 (JVY19_12735) 2545553..2545942 + 390 WP_273119893.1 cupin domain-containing protein -
JVY19_RS12730 (JVY19_12740) 2546212..2547342 + 1131 WP_031598909.1 Fic family protein -
JVY19_RS12735 (JVY19_12745) 2547407..2547619 + 213 WP_031598911.1 helix-turn-helix domain-containing protein -
JVY19_RS12740 (JVY19_12750) 2547824..2548093 - 270 Protein_2501 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2536180..2561201 25021


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11711.55 Da        Isoelectric Point: 8.5354

>T193837 WP_031598903.1 NZ_CP070327:2545017-2545343 [Ferrovum myxofaciens]
MRRGDIYLVSLDPTEGREQRGSRPVLVVSPAEFNEATNLPVICPITNGGDFARRIGFAVPVTGIKTTGVVRCDQPRVLDF
GARNARKVDTLPASIMEEVLAKLATIFA

Download         Length: 327 bp

>T193837 NZ_CP093239:397368-397541 [Escherichia marmotae]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTCTCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGCCTGCCCGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9039.35 Da        Isoelectric Point: 4.6646

>AT193837 WP_062188497.1 NZ_CP070327:2544763-2545020 [Ferrovum myxofaciens]
MHTTNLRKVGGSVMLAVPPAFLDQLHLQAGATVGVVVADGCLVVDPKPRPRYTLAELLAASDYSKPQSAEEREWVDAPAV
GDELV

Download         Length: 258 bp

>AT193837 NZ_CP093239:397045-397341 [Escherichia marmotae]
ATGGAAGGTATAAACAGGTTCAAAACTTACGTTGTTTCTTTTGATTATCCATCATCTTATTACTCAGTTTTCTTAAGGTT
AAGGTCGTTAATGTATGATATGGATTTCTCCTCTATAGTTGCTGATGAATATGGAATACCACGACAATTGAATGAGAATG
CTTTCGCAATAACGACATCATTAGCCGCAAGTGAAATTGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCAGATATT
GATTTTGACCTCAACATTATGATAGTCGATGACTATTTCCGTCAGTTCTACAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References