Detailed information of TA system TA193836

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2376812..2377467
• Replicon: chromosome
• Accession: NZ_CP070327
• Organism: MAG: Ferrovum myxofaciens isolate MI1I

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A8F3E1T1
• Locus tag: JVY19_RS11865
• Protein ID: WP_062188107.1
• Coordinates: 2377069..2377467 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8F3DSV8
• Locus tag: JVY19_RS11860
• Protein ID: WP_062188108.1
• Coordinates: 2376812..2377072 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JVY19_RS11845 (JVY19_11855)	2373152..2374156	-	1005	WP_035417717.1	GNAT family N-acetyltransferase	-
JVY19_RS11850 (JVY19_11860)	2374153..2375403	-	1251	WP_273144433.1	DegT/DnrJ/EryC1/StrS family aminotransferase	-
JVY19_RS11855 (JVY19_11865)	2375570..2376316	-	747	WP_273144435.1	PEP-CTERM sorting domain-containing protein	-
JVY19_RS11860 (JVY19_11870)	2376812..2377072	+	261	WP_062188108.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
JVY19_RS11865 (JVY19_11875)	2377069..2377467	+	399	WP_062188107.1	type II toxin-antitoxin system VapC family toxin	Toxin
JVY19_RS11870 (JVY19_11880)	2377501..2378067	+	567	WP_264753749.1	aminodeoxychorismate/anthranilate synthase component II	-
JVY19_RS11875 (JVY19_11885)	2378033..2378833	-	801	WP_051862509.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
JVY19_RS11880 (JVY19_11890)	2378830..2379819	-	990	WP_031598035.1	4-hydroxythreonine-4-phosphate dehydrogenase PdxA	-
JVY19_RS11885 (JVY19_11895)	2379809..2381218	-	1410	WP_082783422.1	peptidylprolyl isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2298995..2504459	205464

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (8-56)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14718.11 Da
• Isoelectric Point: 8.6116

>T193836 WP_062188107.1 NZ_CP070327:2377069-2377467 [Ferrovum myxofaciens]
MKRYMLDTNTVSHLLKAHPTVARRMVEVPMASLSISAITEGELLFGLAKRPEAKRLHTAVREFLRRVDVLPWDNAISERY
GTVRADMEKQGNILAPLDLLIAAHALSKGAILVTNDQAFGQVANLLLEDWTN

Nucleotide

• Length: 399 bp

>T193836 NZ_CP093238:c4808937-4808227 [Gordonia alkanivorans]
ATGCCGCCAGCGGATATCCCCAGTAAGAACCGGGTAAACCGCGCAGGAGATACCCTGCGCGCCTTCAGCGAGTTGCTGAG
CGAAGGAAGAGTCGACGAAGTGAGGGAAGCACTCGAAGTCCTCTTCGCATGGCGAACTTCCCACGGCAAGCCGCTGCAGA
CAGCAACGATGGGGCTTCGGTCGCGTGTACAAACCGAGGGGTGCCAAGTAGAGGTATCCCAAAGGCTGAAGCGCGTCCCA
ACAATCATCGACAAGCTCTACCGCGAACCGGGGATGAATCTCGCGCGCATGGCCGATATCGGCGGATGTCGAGCCGTGCT
CAACTCGATCGACGAGGTCCGCCGTGTCGAGAAGCGTCTGTGCAAGAAACGGCCGCCGAAGATCTATCACGATTATATCG
CGGAACCAAAGCCCAGCGGCTACCGCGGAGTTCACGTGATCAGCGTCTATCACGAGCGCCTCATCGAGGTACAGTTGCGA
ACGAGGGTTATGCACGAATGGGCGTTCATGGTTGAACGCGTGACGGGCCAGATCGGCACCGATGTCAAGTCAGGCAGAGG
GCCGCAAGCTGTGCGCGACTGGTTCCAGGCGGTGTCCGAGGCGATGGCACTTGAGGAGCAGGGCTTGACTGTCCATGAGA
CACTTGCAACACGTGTCGCGCAATTGCGCGCCACGGCGCAGCCATACCTACGAGCAGGACGTAACCAATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9897.99 Da
• Isoelectric Point: 4.3410

>AT193836 WP_062188108.1 NZ_CP070327:2376812-2377072 [Ferrovum myxofaciens]
MSQVAKLFLNGRSQAVRLPVAYRFDTKEVFIRQDTETGDVILSRKPMDWDGFFSALQGVDGPVDFLDAEERDQGTQNRDP
FEGWRE

Nucleotide

• Length: 261 bp

>AT193836 NZ_CP093238:c4808230-4807979 [Gordonia alkanivorans]
ATGACCCAGATCAAGCACTTCCTCTTGGTGTTCGATCATGCGCGCGCCGAGCTCCTAGATATTCAGGAGTTCGGGAGTGA
CGCACGGTCCGCGATGCGTGCGTATGCAGAGAAAGAACGTGAGCATCTGAAGGCCGGCGACTCGATCGAGATCGTTCTGA
TCGGCTCCGACTCGCTCGATACAGTGCGTTTGACGCACGCAAATTACTTCGATGGGACAGTGGCCGTCTCTAAGTACTTC
GCGGGGATTTGA