Detailed information of TA system TA193835

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapB(antitoxin)
• Location: 2336044..2336411
• Replicon: chromosome
• Accession: NZ_CP070327
• Organism: MAG: Ferrovum myxofaciens isolate MI1I

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JVY19_RS11665
• Protein ID: WP_273180770.1
• Coordinates: 2336044..2336208 (-)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A859AAH2
• Locus tag: JVY19_RS11670
• Protein ID: WP_031599546.1
• Coordinates: 2336205..2336411 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JVY19_RS11640 (JVY19_11650)	2331236..2334106	+	2871	WP_273144395.1	UvrD-helicase domain-containing protein	-
JVY19_RS11645 (JVY19_11655)	2334187..2334495	+	309	WP_273144396.1	IS66 family insertion sequence element accessory protein TnpB	-
JVY19_RS11650 (JVY19_11660)	2334495..2334704	+	210	WP_197456580.1	IS66 family insertion sequence element accessory protein TnpB	-
JVY19_RS11655 (JVY19_11665)	2335506..2335700	-	195	WP_062188518.1	hypothetical protein	-
JVY19_RS11660 (JVY19_11670)	2335827..2336009	-	183	WP_273180767.1	hypothetical protein	-
JVY19_RS11665 (JVY19_11675)	2336044..2336208	-	165	WP_273180770.1	hypothetical protein	Toxin
JVY19_RS11670 (JVY19_11680)	2336205..2336411	-	207	WP_031599546.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JVY19_RS11675 (JVY19_11685)	2336714..2337103	-	390	WP_031598816.1	nucleotidyltransferase domain-containing protein	-
JVY19_RS11680 (JVY19_11690)	2337202..2337621	-	420	WP_062188503.1	type II toxin-antitoxin system VapC family toxin	-
JVY19_RS11685 (JVY19_11695)	2337608..2337868	-	261	WP_031598819.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
JVY19_RS11690 (JVY19_11700)	2338094..2339266	-	1173	WP_062188502.1	glycosyltransferase family 4 protein	-
JVY19_RS11695 (JVY19_11705)	2339272..2340486	-	1215	WP_031598823.1	glycosyltransferase, exosortase A system-associated	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2298995..2504459	205464
	-	flank	IS/Tn	-	-	2334495..2334704	209

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-44)

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 5768.61 Da
• Isoelectric Point: 4.1114

>T193835 WP_273180770.1 NZ_CP070327:c2336208-2336044 [Ferrovum myxofaciens]
MSVLIDTSVWIDHFRNGNDALIDLIGLDLALTHPMVILEIACGTPPSATHPDTG

Nucleotide

• Length: 165 bp

>T193835 NZ_CP093238:c1651025-1650735 [Gordonia alkanivorans]
ATGAACGACGCTCCGACAGACTCGCCCGCCCCCTACCGGGTCGAGGTCGCATCCCCAGCTCGCCGCGACCTTCAACGCCT
TCCATCCCGGATCGTCCACGCCGTCATCGAGTTCATCTCCGGACCCCTCGCCGAGAACCCGCACCGGCTCAGCAAACCGC
TGCGCGACGACCTCGGAGGCCTCCACAGCGCCCGCCGCGGTGACTACCGGGTCCTGCTGCGCATCGACGACCCCAACCAC
ACCATCGTCGTCGTCAGAATCGACCACCGTGCCCACGCATATCGCACCTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7775.06 Da
• Isoelectric Point: 8.6365

>AT193835 WP_031599546.1 NZ_CP070327:c2336411-2336205 [Ferrovum myxofaciens]
MRTTVTIDDALYEKALEMADPNMDKSDIFREAIKTFVRVQAAKRLATLGGMIPKIQDVPRRREEPVVQ

Nucleotide

• Length: 207 bp

>AT193835 NZ_CP093238:c1651297-1651022 [Gordonia alkanivorans]
ATGACTACAGTGCCACTCGGCGAGGCCAAGGACAAGCTCTCCGCGCTCATCGACAGCGCCGAGACCACGCACGACATCAT
CACGATCACCAAGCACGGCAAACCCGCCGCGGTGCTGATGTCGGCCGACGACCTCGAATCGTTGCACGAGACGATCTACT
GGCTCTCACGTGCCGGTCTCCGCGACGACGTCGCCACCGCCGACGCCGAGTACGCCGCCGGCCACACCGTCTCCATCGAC
GACCTGCGCGCCGAACACGGCCTGCCGCCGAAATGA