Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2324723..2326268 Replicon chromosome
Accession NZ_CP070327
Organism MAG: Ferrovum myxofaciens isolate MI1I

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag JVY19_RS11590 Protein ID WP_273144385.1
Coordinates 2324723..2326018 (-) Length 432 a.a.

Antitoxin (Protein)


Gene name HipB2 Uniprot ID A0A8F3DWC8
Locus tag JVY19_RS11595 Protein ID WP_031596370.1
Coordinates 2326008..2326268 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JVY19_RS11555 (JVY19_11565) 2321129..2321380 - 252 WP_273146093.1 hypothetical protein -
JVY19_RS11560 (JVY19_11570) 2321839..2322171 + 333 WP_031598571.1 helix-turn-helix domain-containing protein -
JVY19_RS11565 (JVY19_11575) 2322161..2323411 + 1251 WP_273144380.1 HipA domain-containing protein -
JVY19_RS11570 (JVY19_11580) 2323591..2323767 + 177 WP_273119555.1 type II toxin-antitoxin system HicA family toxin -
JVY19_RS11575 (JVY19_11585) 2323781..2324200 + 420 WP_273144382.1 type II toxin-antitoxin system HicB family antitoxin -
JVY19_RS11580 (JVY19_11590) 2324319..2324513 - 195 WP_062188518.1 hypothetical protein -
JVY19_RS11585 (JVY19_11595) 2324512..2324658 + 147 WP_197456531.1 hypothetical protein -
JVY19_RS11590 (JVY19_11600) 2324723..2326018 - 1296 WP_273144385.1 type II toxin-antitoxin system HipA family toxin Toxin
JVY19_RS11595 (JVY19_11605) 2326008..2326268 - 261 WP_031596370.1 helix-turn-helix transcriptional regulator Antitoxin
JVY19_RS11600 (JVY19_11610) 2326267..2326404 + 138 WP_273180762.1 hypothetical protein -
JVY19_RS11605 (JVY19_11615) 2326398..2327099 - 702 WP_062188520.1 UPF0149 family protein -
JVY19_RS11610 (JVY19_11620) 2327196..2327594 - 399 WP_273144194.1 transposase -
JVY19_RS11615 (JVY19_11625) 2327524..2328414 - 891 WP_273180764.1 transposase -
JVY19_RS11620 (JVY19_11630) 2328435..2328848 + 414 WP_082783440.1 IS200/IS605 family transposase -
JVY19_RS11625 (JVY19_11635) 2328858..2329001 + 144 WP_273144389.1 hypothetical protein -
JVY19_RS11630 (JVY19_11640) 2329276..2329683 + 408 WP_273144391.1 IS200/IS605 family transposase -
JVY19_RS11635 (JVY19_11645) 2329680..2331206 + 1527 WP_273144393.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2298995..2504459 205464
- flank IS/Tn - - 2328483..2328848 365


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-63)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 47508.49 Da        Isoelectric Point: 6.7319

>T193834 WP_273144385.1 NZ_CP070327:c2326018-2324723 [Ferrovum myxofaciens]
MAHELEVWLFADRAGTLTLVAGRLAFCYDPNWLSRPQAVALSVSLPLQAEPFDDHKTRPFFAGLLPEGQMRRLIAQQFQV
SNQNDFALLDHIGGECAGAVTFLEPGQALPASTQCEDIQWLSNEEVIAILDELPHRPMLAGKDGLRLSLAGAQDKLPVVF
DGARIGLPHNGTPSSHILKPPIHAVEDSVANEGFCLTLANTLQLKPAKAKVHSIGTRSFLLVERYDRSLDKVGHRRRIHQ
EDFCQALGVVPEIKYQNEGGPDLAQCFDLVRRVSRPSAPQVLRLLDYVIFNALTGNHDAHAKNFSLLYLIEGPVLAPFYD
TLSTAVYPMLTPKMAMKIGSKYKFSEIQARHWDQLAEGAGLAKALTKKRILELAKSLPPTARKIQSDPGHGFSGNAVVER
IIALIEQRCALTIRRLTDPAVDNEDDTEPSS

Download         Length: 1296 bp

>T193834 NZ_CP093229:2257-2535 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGTCGCAACGGTCGTG
TGGAAGGAACCCGGGAACTGGTTATTCACCCCCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
GTCCTGCGCGTGTTGCATACCGCACAGAAGTGGCCATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9023.37 Da        Isoelectric Point: 6.2463

>AT193834 WP_031596370.1 NZ_CP070327:c2326268-2326008 [Ferrovum myxofaciens]
MTTIRSPQQLGDALRAARKQLALTQPQLALAAGVGVRFIVDLEAGKPTLRLENVLRVIDALGGEIIISGLPSGVAEDQRS
GNDYGA

Download         Length: 261 bp

>AT193834 NZ_CP093229:1988-2257 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCCGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTTCCGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References