Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1289297..1290072 Replicon chromosome
Accession NZ_CP070327
Organism MAG: Ferrovum myxofaciens isolate MI1I

Toxin (Protein)


Gene name tacT Uniprot ID A0A859A802
Locus tag JVY19_RS06305 Protein ID WP_031596033.1
Coordinates 1289297..1289791 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A859AAZ0
Locus tag JVY19_RS06310 Protein ID WP_031596032.1
Coordinates 1289788..1290072 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JVY19_RS06290 (JVY19_06310) 1285107..1288160 - 3054 WP_273146015.1 PAS domain S-box protein -
JVY19_RS06295 (JVY19_06315) 1288359..1288610 + 252 WP_031596035.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JVY19_RS06300 (JVY19_06320) 1288607..1288993 + 387 WP_031596034.1 type II toxin-antitoxin system VapC family toxin -
JVY19_RS06305 (JVY19_06325) 1289297..1289791 - 495 WP_031596033.1 GNAT family N-acetyltransferase Toxin
JVY19_RS06310 (JVY19_06330) 1289788..1290072 - 285 WP_031596032.1 DUF1778 domain-containing protein Antitoxin
JVY19_RS06315 (JVY19_06335) 1290347..1290562 - 216 WP_273146017.1 hypothetical protein -
JVY19_RS06320 (JVY19_06340) 1291396..1292268 + 873 WP_273121346.1 hypothetical protein -
JVY19_RS06325 (JVY19_06345) 1292479..1293465 + 987 WP_273146021.1 GTP 3',8-cyclase MoaA -
JVY19_RS06330 (JVY19_06350) 1293505..1294044 + 540 WP_273121353.1 molybdopterin adenylyltransferase -
JVY19_RS06335 (JVY19_06355) 1294041..1294532 + 492 WP_273146023.1 molybdopterin-guanine dinucleotide biosynthesis protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(4-93)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18208.89 Da        Isoelectric Point: 8.5067

>T193831 WP_031596033.1 NZ_CP070327:c1289791-1289297 [Ferrovum myxofaciens]
MSLSAPQSLDANHRLEEFDCGKPALTDWLLRHARQAQGSGSAKTFVACDGSRVAGYFSLTVGQIDTLEAPERIRRGMGQY
PIPLVILARLAVDLDYQKQGLGFSLLQDAIRRTVAIAEHAGIRALLTHPIDAEAETFYRRFGFASTPVREQQLILLLKDA
RRFV

Download         Length: 495 bp

>T193831 NZ_CP093227:103700-104005 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCTGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10516.92 Da        Isoelectric Point: 6.4651

>AT193831 WP_031596032.1 NZ_CP070327:c1290072-1289788 [Ferrovum myxofaciens]
MTATTTARSARLGLRATPEQETVLRRAAEVAHKSLTDFILDAAYQAAEHTLLDQRLFMVSGSQYQALLEMLDRPESDNPG
LANLFSRRPVWAEK

Download         Length: 285 bp

>AT193831 NZ_CP093227:103480-103698 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References