Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1079782..1080326 Replicon chromosome
Accession NZ_CP070327
Organism MAG: Ferrovum myxofaciens isolate MI1I

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JVY19_RS05265 Protein ID WP_031596839.1
Coordinates 1079782..1080108 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag JVY19_RS05270 Protein ID WP_082783138.1
Coordinates 1080105..1080326 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JVY19_RS05240 (JVY19_05260) 1075577..1076161 + 585 WP_273145884.1 chorismate lyase -
JVY19_RS05245 (JVY19_05265) 1076240..1076881 + 642 WP_062187741.1 response regulator transcription factor -
JVY19_RS05250 (JVY19_05270) 1076889..1079024 - 2136 WP_273145885.1 DUF748 domain-containing protein -
JVY19_RS05255 (JVY19_05275) 1079028..1079180 - 153 WP_273145886.1 hypothetical protein -
JVY19_RS05260 (JVY19_05280) 1079177..1079611 - 435 WP_150112405.1 cytochrome C -
JVY19_RS05265 (JVY19_05285) 1079782..1080108 - 327 WP_031596839.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JVY19_RS05270 (JVY19_05290) 1080105..1080326 - 222 WP_082783138.1 antitoxin MazE family protein Antitoxin
JVY19_RS05275 (JVY19_05295) 1080561..1080899 + 339 WP_031599590.1 toxin -
JVY19_RS05280 (JVY19_05300) 1080896..1081210 + 315 WP_031599591.1 transcriptional regulator -
JVY19_RS05285 (JVY19_05305) 1081716..1081937 - 222 WP_082783138.1 antitoxin MazE family protein -
JVY19_RS05290 (JVY19_05310) 1082106..1082528 - 423 WP_031599221.1 type II toxin-antitoxin system VapC family toxin -
JVY19_RS05295 (JVY19_05315) 1082525..1082839 - 315 WP_031599223.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
JVY19_RS05300 (JVY19_05320) 1083166..1085061 - 1896 WP_062187752.1 GGDEF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-105)

Antitoxin

Antitoxin MazE-like

(7-71)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11683.81 Da        Isoelectric Point: 9.2533

>T193829 WP_031596839.1 NZ_CP070327:c1080108-1079782 [Ferrovum myxofaciens]
MMRGDFVTIVMQGDFGKPRPALVIQADQFGEHATVTVLPMTSTLVAAPLLRTPIQPSAENGLNKPSQVMIDKAMTVKRDK
LGQAFGRIDGVVMTEVERCLAVFLGIAK

Download         Length: 327 bp

>T193829 NZ_CP093227:57698-57847 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8652.76 Da        Isoelectric Point: 5.5794

>AT193829 WP_082783138.1 NZ_CP070327:c1080326-1080105 [Ferrovum myxofaciens]
MATHVNTRVQRHRDTLRMAGLRPIQIWVPDTRRPDFAEECRRQSRLVAQTDMVDTDLQHFMDEALADMEGWTE

Download         Length: 222 bp

>AT193829 NZ_CP093227:c57654-57593 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References