Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1633610..1634087 Replicon chromosome
Accession NZ_CP070306
Organism Staphylococcus sp. SM9054

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag JQN77_RS08005 Protein ID WP_000052076.1
Coordinates 1633610..1633798 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag JQN77_RS08010 Protein ID WP_001059690.1
Coordinates 1633827..1634087 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQN77_RS07975 1629652..1630122 + 471 WP_000824472.1 hypothetical protein -
JQN77_RS07980 1630463..1631149 + 687 WP_001548082.1 thermonuclease family protein -
JQN77_RS07985 1631506..1631706 + 201 WP_001059082.1 cold-shock protein -
JQN77_RS07990 1632201..1632419 - 219 WP_000005884.1 hypothetical protein -
JQN77_RS07995 1632481..1632765 - 285 WP_001004394.1 hypothetical protein -
JQN77_RS08000 1632853..1633422 - 570 WP_001106653.1 hypothetical protein -
JQN77_RS08005 1633610..1633798 - 189 WP_000052076.1 hypothetical protein Toxin
JQN77_RS08010 1633827..1634087 - 261 WP_001059690.1 hypothetical protein Antitoxin
JQN77_RS08015 1634428..1634631 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
JQN77_RS08020 1634628..1634864 - 237 WP_000368687.1 hypothetical protein -
JQN77_RS08025 1635089..1635670 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
JQN77_RS08030 1635743..1636360 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
JQN77_RS08035 1636515..1637009 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
JQN77_RS08040 1637408..1637830 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
JQN77_RS08045 1637978..1638694 + 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T193824 WP_000052076.1 NZ_CP070306:c1633798-1633610 [Staphylococcus sp. SM9054]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T193824 NZ_CP093226:3722411-3722689 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT193824 WP_001059690.1 NZ_CP070306:c1634087-1633827 [Staphylococcus sp. SM9054]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT193824 NZ_CP093226:3722148-3722408 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References