Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 80702..81216 Replicon chromosome
Accession NZ_CP070306
Organism Staphylococcus sp. SM9054

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JQN77_RS00430 Protein ID WP_000581792.1
Coordinates 80702..80911 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JQN77_RS00435 Protein ID WP_000138932.1
Coordinates 80923..81216 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQN77_RS00410 76210..77568 - 1359 WP_000611471.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JQN77_RS00415 77583..78653 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
JQN77_RS00420 78971..80173 + 1203 WP_001836940.1 rod shape-determining protein RodA -
JQN77_RS00425 80437..80574 - 138 WP_000828354.1 hypothetical protein -
JQN77_RS00430 80702..80911 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
JQN77_RS00435 80923..81216 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JQN77_RS00440 81382..82866 + 1485 WP_000571549.1 cardiolipin synthase -
JQN77_RS00445 82894..83541 + 648 WP_001187630.1 HD domain-containing protein -
JQN77_RS00450 84146..85018 - 873 WP_000725802.1 membrane protein insertase YidC -
JQN77_RS00455 85104..85745 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T193819 WP_000581792.1 NZ_CP070306:c80911-80702 [Staphylococcus sp. SM9054]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T193819 NZ_CP093226:c2442847-2442671 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT193819 WP_000138932.1 NZ_CP070306:c81216-80923 [Staphylococcus sp. SM9054]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT193819 NZ_CP093226:c2442625-2442209 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References