Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1636364..1636841 Replicon chromosome
Accession NZ_CP070305
Organism Staphylococcus sp. SM3655

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag JQN76_RS08020 Protein ID WP_000052076.1
Coordinates 1636364..1636552 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag JQN76_RS08025 Protein ID WP_001059690.1
Coordinates 1636581..1636841 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQN76_RS07990 1632406..1632876 + 471 WP_000824472.1 hypothetical protein -
JQN76_RS07995 1633217..1633903 + 687 WP_001548082.1 thermonuclease family protein -
JQN76_RS08000 1634260..1634460 + 201 WP_001059082.1 cold-shock protein -
JQN76_RS08005 1634955..1635173 - 219 WP_000005884.1 hypothetical protein -
JQN76_RS08010 1635235..1635519 - 285 WP_001004394.1 hypothetical protein -
JQN76_RS08015 1635607..1636176 - 570 WP_001106653.1 hypothetical protein -
JQN76_RS08020 1636364..1636552 - 189 WP_000052076.1 hypothetical protein Toxin
JQN76_RS08025 1636581..1636841 - 261 WP_001059690.1 hypothetical protein Antitoxin
JQN76_RS08030 1637182..1637385 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
JQN76_RS08035 1637382..1637618 - 237 WP_000368687.1 hypothetical protein -
JQN76_RS08040 1637843..1638424 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
JQN76_RS08045 1638497..1639114 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
JQN76_RS08050 1639269..1639763 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
JQN76_RS08055 1640162..1640584 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
JQN76_RS08060 1640732..1641448 + 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T193812 WP_000052076.1 NZ_CP070305:c1636552-1636364 [Staphylococcus sp. SM3655]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T193812 NZ_CP093226:929592-929999 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT193812 WP_001059690.1 NZ_CP070305:c1636841-1636581 [Staphylococcus sp. SM3655]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT193812 NZ_CP093226:929345-929611 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References