Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 83451..83965 Replicon chromosome
Accession NZ_CP070305
Organism Staphylococcus sp. SM3655

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JQN76_RS00445 Protein ID WP_000581792.1
Coordinates 83451..83660 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JQN76_RS00450 Protein ID WP_000138932.1
Coordinates 83672..83965 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQN76_RS00425 78959..80317 - 1359 WP_000611471.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JQN76_RS00430 80332..81402 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
JQN76_RS00435 81720..82922 + 1203 WP_001836940.1 rod shape-determining protein RodA -
JQN76_RS00440 83186..83323 - 138 WP_000828354.1 hypothetical protein -
JQN76_RS00445 83451..83660 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
JQN76_RS00450 83672..83965 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JQN76_RS00455 84131..85615 + 1485 WP_000571549.1 cardiolipin synthase -
JQN76_RS00460 85643..86290 + 648 WP_001187630.1 HD domain-containing protein -
JQN76_RS00465 86895..87767 - 873 WP_000725802.1 membrane protein insertase YidC -
JQN76_RS00470 87853..88494 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T193807 WP_000581792.1 NZ_CP070305:c83660-83451 [Staphylococcus sp. SM3655]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T193807 NZ_CP093226:185984-186091 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT193807 WP_000138932.1 NZ_CP070305:c83965-83672 [Staphylococcus sp. SM3655]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT193807 NZ_CP093226:c185936-185870 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References