Detailed information of TA system TA193805

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 9791..10302
• Replicon: chromosome
• Accession: NZ_CP070305
• Organism: Staphylococcus sp. SM3655

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: JQN76_RS00070
• Protein ID: WP_001103943.1
• Coordinates: 9791..10090 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: JQN76_RS00075
• Protein ID: WP_001058486.1
• Coordinates: 10093..10302 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQN76_RS00040	4941..5519	-	579	WP_000846292.1	hypothetical protein	-
JQN76_RS00045	5531..5872	-	342	WP_001161659.1	hypothetical protein	-
JQN76_RS00050	6219..6860	-	642	WP_001836978.1	pathogenicity island protein	-
JQN76_RS00055	6862..7134	-	273	WP_001149387.1	hypothetical protein	-
JQN76_RS00060	7121..7924	-	804	WP_000148374.1	bifunctional DNA primase/polymerase	-
JQN76_RS00065	8100..9716	-	1617	WP_000344761.1	hypothetical protein	-
JQN76_RS00070	9791..10090	-	300	WP_001103943.1	DUF1474 family protein	Toxin
JQN76_RS00075	10093..10302	-	210	WP_001058486.1	hypothetical protein	Antitoxin
JQN76_RS00080	10295..10441	-	147	WP_000784875.1	hypothetical protein	-
JQN76_RS00085	10438..10755	-	318	WP_000459698.1	helix-turn-helix domain-containing protein	-
JQN76_RS00090	10759..10971	-	213	WP_000794315.1	helix-turn-helix transcriptional regulator	-
JQN76_RS00095	11145..11777	+	633	WP_000616253.1	helix-turn-helix transcriptional regulator	-
JQN76_RS00100	11786..12958	+	1173	WP_000179352.1	site-specific integrase	-
JQN76_RS00105	13027..14643	-	1617	WP_000240645.1	chaperonin GroEL	-
JQN76_RS00110	14719..15003	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	3217..15003	11786

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11795.24 Da
• Isoelectric Point: 4.5689

>T193805 WP_001103943.1 NZ_CP070305:c10090-9791 [Staphylococcus sp. SM3655]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDA

Nucleotide

• Length: 300 bp

>T193805 NZ_CP093222:927521-927700 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT193805 WP_001058486.1 NZ_CP070305:c10302-10093 [Staphylococcus sp. SM3655]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT193805 NZ_CP093222:926898-927497 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAATTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA