Detailed information of TA system TA193793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 11908..12430
• Replicon: plasmid pESA136_2
• Accession: NZ_CP070298
• Organism: Escherichia albertii strain Sample 165

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: JRC44_RS24875
• Protein ID: WP_000220560.1
• Coordinates: 11908..12189 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: JRC44_RS24880
• Protein ID: WP_000121743.1
• Coordinates: 12179..12430 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC44_RS24825 (7748)	7748..8914	-	1167	WP_208629828.1	MobP1 family relaxase	-
JRC44_RS24830 (8917)	8917..9462	-	546	WP_074557685.1	DNA distortion polypeptide 1	-
JRC44_RS24840 (9793)	9793..10065	-	273	WP_000160399.1	hypothetical protein	-
JRC44_RS24845 (10078)	10078..10227	-	150	WP_000003880.1	hypothetical protein	-
JRC44_RS24850 (10297)	10297..10476	-	180	WP_000439079.1	hypothetical protein	-
JRC44_RS24855 (10520)	10520..10849	-	330	WP_000866656.1	hypothetical protein	-
JRC44_RS24860 (10942)	10942..11157	-	216	WP_001180117.1	hypothetical protein	-
JRC44_RS24865 (11147)	11147..11392	-	246	WP_024202098.1	hypothetical protein	-
JRC44_RS24870 (11440)	11440..11763	-	324	WP_001181905.1	hypothetical protein	-
JRC44_RS24875 (11908)	11908..12189	-	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JRC44_RS24880 (12179)	12179..12430	-	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
JRC44_RS24885 (13495)	13495..14364	+	870	WP_032347905.1	replication initiation protein	-
JRC44_RS24890 (14369)	14369..15220	+	852	WP_206299233.1	replication initiation protein	-
JRC44_RS24895 (15224)	15224..15667	+	444	WP_109542532.1	hypothetical protein	-
JRC44_RS24900 (15807)	15807..16163	+	357	WP_244251468.1	DNA distortion polypeptide 3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	cofA	1..69682	69682

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11005.83 Da
• Isoelectric Point: 10.5938

>T193793 WP_000220560.1 NZ_CP070298:c12189-11908 [Escherichia albertii]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Nucleotide

• Length: 282 bp

>T193793 NZ_CP093221:c2923802-2923428 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9194.43 Da
• Isoelectric Point: 4.1683

>AT193793 WP_000121743.1 NZ_CP070298:c12430-12179 [Escherichia albertii]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Nucleotide

• Length: 252 bp

>AT193793 NZ_CP093221:c2924259-2923891 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301