Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4422092..4423017 Replicon chromosome
Accession NZ_CP070296
Organism Escherichia albertii strain Sample 165

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag JRC44_RS21560 Protein ID WP_014640052.1
Coordinates 4422092..4422478 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag JRC44_RS21565 Protein ID WP_001339382.1
Coordinates 4422508..4423017 (-) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC44_RS21525 (4417970) 4417970..4418176 - 207 WP_208629539.1 DUF4222 domain-containing protein -
JRC44_RS21540 (4419623) 4419623..4420195 + 573 WP_208629540.1 3'-5' exonuclease -
JRC44_RS21545 (4420232) 4420232..4420513 + 282 WP_001093922.1 pyocin activator PrtN family protein -
JRC44_RS21550 (4420706) 4420706..4421740 - 1035 WP_208629542.1 competence protein CoiA family protein -
JRC44_RS21555 (4421879) 4421879..4422052 - 174 WP_000390070.1 hypothetical protein -
JRC44_RS21560 (4422092) 4422092..4422478 - 387 WP_014640052.1 hypothetical protein Toxin
JRC44_RS21565 (4422508) 4422508..4423017 - 510 WP_001339382.1 Panacea domain-containing protein Antitoxin
JRC44_RS21570 (4423552) 4423552..4424067 + 516 WP_002460756.1 zinc uptake transcriptional repressor Zur -
JRC44_RS21575 (4424108) 4424108..4424317 - 210 WP_001030604.1 CsbD family protein -
JRC44_RS21580 (4424433) 4424433..4425758 - 1326 WP_025237884.1 MATE family efflux transporter DinF -
JRC44_RS21585 (4425833) 4425833..4426441 - 609 WP_000646078.1 transcriptional repressor LexA -
JRC44_RS21590 (4426551) 4426551..4426919 - 369 WP_000002912.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4404541..4426441 21900


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T193791 WP_014640052.1 NZ_CP070296:c4422478-4422092 [Escherichia albertii]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T193791 NZ_CP093221:2911658-2911909 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19576.29 Da        Isoelectric Point: 5.3338

>AT193791 WP_001339382.1 NZ_CP070296:c4423017-4422508 [Escherichia albertii]
MAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHNVSLRSDPREMDAD
EVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp

>AT193791 NZ_CP093221:2911906-2912160 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References