Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2536602..2537206 Replicon chromosome
Accession NZ_CP070296
Organism Escherichia albertii strain Sample 165

Toxin (Protein)


Gene name doc Uniprot ID B1EM00
Locus tag JRC44_RS12420 Protein ID WP_000638401.1
Coordinates 2536602..2536988 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag JRC44_RS12425 Protein ID WP_001195490.1
Coordinates 2536985..2537206 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC44_RS12415 (2532983) 2532983..2536522 + 3540 WP_244251444.1 autotransporter outer membrane beta-barrel domain-containing protein -
JRC44_RS12420 (2536602) 2536602..2536988 - 387 WP_000638401.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
JRC44_RS12425 (2536985) 2536985..2537206 - 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JRC44_RS26805 (2538036) 2538036..2538161 + 126 WP_263751137.1 hypothetical protein -
JRC44_RS12430 (2538225) 2538225..2539445 - 1221 WP_001026226.1 type II secretion system protein GspD -
JRC44_RS12435 (2539455) 2539455..2540711 - 1257 WP_001687537.1 zonular occludens toxin domain-containing protein -
JRC44_RS12440 (2540719) 2540719..2541078 - 360 WP_001111980.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14505.49 Da        Isoelectric Point: 8.0833

>T193783 WP_000638401.1 NZ_CP070296:c2536988-2536602 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

>T193783 NZ_CP093221:1305618-1305725 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT193783 WP_001195490.1 NZ_CP070296:c2537206-2536985 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp

>AT193783 NZ_CP093221:c1305570-1305504 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T5VDW2

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References