Detailed information of TA system TA193767

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 145550..146162
• Replicon: chromosome
• Accession: NZ_CP070296
• Organism: Escherichia albertii strain Sample 165

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: U9YXE2
• Locus tag: JRC44_RS00645
• Protein ID: WP_000833473.1
• Coordinates: 145550..145735 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: L4IWR9
• Locus tag: JRC44_RS00650
• Protein ID: WP_000499744.1
• Coordinates: 145752..146162 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC44_RS00630 (141014)	141014..142309	+	1296	WP_025238096.1	Fic family protein	-
JRC44_RS00635 (142417)	142417..143955	+	1539	WP_010327692.1	aldehyde dehydrogenase AldB	-
JRC44_RS00640 (143996)	143996..145075	-	1080	WP_025238097.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
JRC44_RS00645 (145550)	145550..145735	+	186	WP_000833473.1	type II toxin-antitoxin system HicA family toxin	Toxin
JRC44_RS00650 (145752)	145752..146162	+	411	WP_000499744.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JRC44_RS00655 (146234)	146234..148198	-	1965	WP_208629574.1	glycoside hydrolase family 127 protein	-
JRC44_RS00660 (148209)	148209..149609	-	1401	WP_025238099.1	MFS transporter	-
JRC44_RS00665 (149835)	149835..150650	+	816	WP_025238100.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6800.89 Da
• Isoelectric Point: 11.7053

>T193767 WP_000833473.1 NZ_CP070296:145550-145735 [Escherichia albertii]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Nucleotide

• Length: 186 bp

>T193767 NZ_CP093212:999497-999892 [Staphylococcus epidermidis]
ATGCAAAGCACTAAATATTTAACTGAAAAACAAGTGATTGCCATTAATGTAAAAGCAATACAAGATTTCTCACCAAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAAGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTCGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCAGCTTTTATATATAGAAATATAGCTCAAAAGCACGCATTCCATAATGCGAATAAAAGA
ACAGCTTTTACATCTATGGTAATATTTTTGAAGTTAAATAGTATTAATTTTGAATGCACTCAAGATGAAGCGGTTCAGTT
TACTTTAAGAGTAGTAAACGACAAAAATCTTACTCTTGAGGGAATTGAGACATGGATCAAGAGGCATTGTAAATAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 15241.15 Da
• Isoelectric Point: 4.5486

>AT193767 WP_000499744.1 NZ_CP070296:145752-146162 [Escherichia albertii]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Nucleotide

• Length: 411 bp

>AT193767 NZ_CP093212:999267-999497 [Staphylococcus epidermidis]
ATGATTACTACAAGAAAACTAAGAAAAGCTGGTAATAGTTCAGTTGTTTCTGTACCGACAGAAGTGATCGCAGCACTCGG
AATATCAAATGGTGATAATCTTAAATTTAATGTAAAAGATAATAAAGTAACCATCGAAAAGGAGGTAAGAGAGGACGAGG
AGTTTTTTAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTTTAAAAAGGATGGTTGACTTATAA

Structures

Toxin

• AlphaFold DB: U9YXE2

Antitoxin

• AlphaFold DB: L4IWR9