Detailed information of TA system TA193765

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 72891..73413
• Replicon: plasmid pESA139_2
• Accession: NZ_CP070294
• Organism: Escherichia albertii strain Sample 166

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JRC43_RS24600
• Protein ID: WP_137649391.1
• Coordinates: 72891..73172 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: JRC43_RS24605
• Protein ID: WP_000121743.1
• Coordinates: 73162..73413 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC43_RS24540 (68217)	68217..68465	-	249	Protein_82	DNA distortion polypeptide 1	-
JRC43_RS24545 (68581)	68581..68769	+	189	WP_000957857.1	hypothetical protein	-
JRC43_RS24550 (68779)	68779..69978	+	1200	WP_000948429.1	IS91 family transposase	-
JRC43_RS24555 (70151)	70151..70450	-	300	Protein_85	DNA distortion polypeptide 1	-
JRC43_RS24565 (70791)	70791..71048	-	258	WP_074160415.1	hypothetical protein	-
JRC43_RS24570 (71061)	71061..71210	-	150	WP_171002983.1	hypothetical protein	-
JRC43_RS24575 (71280)	71280..71459	-	180	WP_000439079.1	hypothetical protein	-
JRC43_RS24580 (71502)	71502..71831	-	330	WP_000866654.1	hypothetical protein	-
JRC43_RS24585 (71924)	71924..72139	-	216	WP_001180117.1	hypothetical protein	-
JRC43_RS24590 (72129)	72129..72374	-	246	WP_137649390.1	hypothetical protein	-
JRC43_RS24595 (72422)	72422..72745	-	324	WP_001181905.1	hypothetical protein	-
JRC43_RS24600 (72891)	72891..73172	-	282	WP_137649391.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JRC43_RS24605 (73162)	73162..73413	-	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
JRC43_RS24610 (74609)	74609..75445	+	837	WP_061873651.1	replication initiation protein	-
JRC43_RS24615 (75485)	75485..75931	+	447	WP_208634906.1	hypothetical protein	-
JRC43_RS24620 (76067)	76067..76423	+	357	WP_244259570.1	DNA distortion polypeptide 3	-
JRC43_RS24625 (76445)	76445..77305	-	861	WP_073534376.1	hypothetical protein	-
JRC43_RS24630 (77323)	77323..77514	-	192	WP_244259571.1	YcxB family protein	-
JRC43_RS25755 (77618)	77618..77917	-	300	WP_073534375.1	aminopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	cofA	1..85397	85397
	-	flank	IS/Tn	-	-	68779..69978	1199

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11049.89 Da
• Isoelectric Point: 10.7380

>T193765 WP_137649391.1 NZ_CP070294:c73172-72891 [Escherichia albertii]
MTYELAFDRRALKEWRKLGHTIREQFKKKLSERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Nucleotide

• Length: 282 bp

>T193765 NZ_CP093212:859374-859583 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9194.43 Da
• Isoelectric Point: 4.1683

>AT193765 WP_000121743.1 NZ_CP070294:c73413-73162 [Escherichia albertii]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Nucleotide

• Length: 252 bp

>AT193765 NZ_CP093212:859074-859367 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A3S5I301