Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 28484..29031 Replicon plasmid pESA139_2
Accession NZ_CP070294
Organism Escherichia albertii strain Sample 166

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag JRC43_RS24340 Protein ID WP_001384452.1
Coordinates 28753..29031 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A7U8WKC6
Locus tag JRC43_RS24335 Protein ID WP_000079946.1
Coordinates 28484..28753 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC43_RS24290 (24103) 24103..24765 + 663 Protein_30 conjugative transfer relaxase/helicase TraI -
JRC43_RS24295 (24758) 24758..25312 + 555 WP_208634911.1 fertility inhibition protein FinO -
JRC43_RS24300 (25448) 25448..25660 + 213 WP_096949658.1 hypothetical protein -
JRC43_RS24305 (25906) 25906..25980 + 75 Protein_33 endonuclease -
- (26236) 26236..26297 - 62 NuclAT_0 - -
- (26236) 26236..26297 - 62 NuclAT_0 - -
- (26236) 26236..26297 - 62 NuclAT_0 - -
- (26236) 26236..26297 - 62 NuclAT_0 - -
JRC43_RS24310 (26341) 26341..26490 + 150 WP_001312851.1 Hok/Gef family protein -
JRC43_RS24315 (26774) 26774..27031 + 258 WP_000083845.1 replication regulatory protein RepA -
JRC43_RS25735 (27048) 27048..27299 - 252 WP_223195197.1 replication protein RepA -
JRC43_RS25740 (27290) 27290..27337 + 48 WP_229471593.1 hypothetical protein -
JRC43_RS24325 (27330) 27330..27812 + 483 WP_001273588.1 hypothetical protein -
JRC43_RS24330 (27805) 27805..28374 + 570 Protein_39 plasmid replication initiator RepA -
JRC43_RS24335 (28484) 28484..28753 + 270 WP_000079946.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
JRC43_RS24340 (28753) 28753..29031 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
JRC43_RS24345 (29077) 29077..29502 + 426 Protein_42 3'-5' exonuclease -
JRC43_RS24350 (29667) 29667..30191 + 525 WP_000823671.1 superoxide dismutase family protein -
JRC43_RS24355 (30453) 30453..30878 + 426 WP_000422741.1 transposase -
JRC43_RS24360 (30875) 30875..31225 + 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
JRC43_RS24365 (31256) 31256..32869 + 1614 WP_000080197.1 IS66-like element ISEc23 family transposase -
JRC43_RS24370 (33050) 33050..34022 - 973 Protein_47 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cofA 1..85397 85397


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T193764 WP_001384452.1 NZ_CP070294:28753-29031 [Escherichia albertii]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T193764 NZ_CP093210:c1657847-1657638 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10210.55 Da        Isoelectric Point: 8.8735

>AT193764 WP_000079946.1 NZ_CP070294:28484-28753 [Escherichia albertii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLGRGDVLPHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT193764 NZ_CP093210:c1658147-1657854 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A7U8WKC6

References