Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2511579..2512183 Replicon chromosome
Accession NZ_CP070292
Organism Escherichia albertii strain Sample 166

Toxin (Protein)


Gene name doc Uniprot ID B1EM00
Locus tag JRC43_RS12345 Protein ID WP_000638401.1
Coordinates 2511797..2512183 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag JRC43_RS12340 Protein ID WP_001195490.1
Coordinates 2511579..2511800 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC43_RS12325 (2507749) 2507749..2508066 + 318 WP_244259545.1 hypothetical protein -
JRC43_RS12330 (2508074) 2508074..2509330 + 1257 WP_001687537.1 zonular occludens toxin domain-containing protein -
JRC43_RS12335 (2509340) 2509340..2510560 + 1221 WP_001026226.1 type II secretion system protein GspD -
JRC43_RS25865 (2510624) 2510624..2510749 - 126 WP_001413216.1 hypothetical protein -
JRC43_RS12340 (2511579) 2511579..2511800 + 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JRC43_RS12345 (2511797) 2511797..2512183 + 387 WP_000638401.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
JRC43_RS12350 (2512283) 2512283..2513326 - 1044 WP_158412295.1 hypothetical protein -
JRC43_RS12360 (2513828) 2513828..2514391 - 564 WP_025237019.1 hypothetical protein -
JRC43_RS25465 (2514402) 2514402..2515630 + 1229 WP_208634731.1 IS3-like element IS2 family transposase -
JRC43_RS25470 (2515914) 2515914..2516657 - 744 Protein_2461 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - nleC / vgrG/tssI 2383594..2638523 254929


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14505.49 Da        Isoelectric Point: 8.0833

>T193746 WP_000638401.1 NZ_CP070292:2511797-2512183 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

>T193746 NZ_CP093202:832905-833114 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT193746 WP_001195490.1 NZ_CP070292:2511579-2511800 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp

>AT193746 NZ_CP093202:832605-832898 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T5VDW2

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References