Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 994241..994892 Replicon chromosome
Accession NZ_CP070292
Organism Escherichia albertii strain Sample 166

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag JRC43_RS04865 Protein ID WP_000244763.1
Coordinates 994488..994892 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JRC43_RS04860 Protein ID WP_000354046.1
Coordinates 994241..994507 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC43_RS04835 (989953) 989953..991386 - 1434 WP_025238420.1 6-phospho-beta-glucosidase BglA -
JRC43_RS04840 (991431) 991431..991742 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
JRC43_RS04845 (991910) 991910..992569 + 660 WP_000250281.1 hemolysin III family protein -
JRC43_RS04850 (993009) 993009..993989 - 981 WP_025238421.1 tRNA-modifying protein YgfZ -
JRC43_RS04855 (994021) 994021..994251 + 231 WP_000181267.1 hypothetical protein -
JRC43_RS04860 (994241) 994241..994507 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JRC43_RS04865 (994488) 994488..994892 + 405 WP_000244763.1 protein YgfX Toxin
JRC43_RS04870 (994931) 994931..995452 - 522 WP_025238422.1 flavodoxin FldB -
JRC43_RS04875 (995564) 995564..996460 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JRC43_RS04880 (996485) 996485..997195 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JRC43_RS04885 (997201) 997201..998934 + 1734 WP_137649287.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T193733 WP_000244763.1 NZ_CP070292:994488-994892 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T193733 NZ_CP093193:859333-859695 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT193733 WP_000354046.1 NZ_CP070292:994241-994507 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT193733 NZ_CP093193:859166-859336 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References