Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 851969..852767 Replicon chromosome
Accession NZ_CP070292
Organism Escherichia albertii strain Sample 166

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag JRC43_RS04135 Protein ID WP_000854735.1
Coordinates 851969..852346 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag JRC43_RS04140 Protein ID WP_032153712.1
Coordinates 852393..852767 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC43_RS04105 (847934) 847934..849199 - 1266 WP_089648449.1 integrase arm-type DNA-binding domain-containing protein -
JRC43_RS04110 (849663) 849663..849989 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
JRC43_RS04115 (849986) 849986..850249 - 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
JRC43_RS04120 (850321) 850321..851187 - 867 WP_032153714.1 DUF4942 domain-containing protein -
JRC43_RS04125 (851272) 851272..851469 - 198 WP_000839265.1 DUF957 domain-containing protein -
JRC43_RS04130 (851481) 851481..851972 - 492 WP_023155722.1 DUF5983 family protein -
JRC43_RS04135 (851969) 851969..852346 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
JRC43_RS04140 (852393) 852393..852767 - 375 WP_032153712.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
JRC43_RS04145 (852847) 852847..853068 - 222 WP_000692345.1 DUF987 domain-containing protein -
JRC43_RS04150 (853137) 853137..853613 - 477 WP_001186715.1 RadC family protein -
JRC43_RS04155 (853629) 853629..854114 - 486 WP_032153711.1 antirestriction protein -
JRC43_RS04160 (854206) 854206..855024 - 819 WP_001234693.1 DUF932 domain-containing protein -
JRC43_RS04165 (855115) 855115..855324 - 210 WP_023155727.1 DUF905 family protein -
JRC43_RS04170 (855354) 855354..856031 - 678 WP_023155728.1 hypothetical protein -
JRC43_RS04175 (856150) 856150..857034 - 885 WP_024166630.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T193732 WP_000854735.1 NZ_CP070292:c852346-851969 [Escherichia albertii]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T193732 NZ_CP093193:848282-848491 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT193732 WP_032153712.1 NZ_CP070292:c852767-852393 [Escherichia albertii]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT193732 NZ_CP093193:847982-848275 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References