Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 66224..66825 | Replicon | plasmid pESA138_1 |
| Accession | NZ_CP070291 | ||
| Organism | Escherichia albertii strain Sample 167 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | JRC41_RS22040 | Protein ID | WP_208631226.1 |
| Coordinates | 66445..66825 (+) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A403D1Y2 |
| Locus tag | JRC41_RS22035 | Protein ID | WP_001190714.1 |
| Coordinates | 66224..66445 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JRC41_RS22450 | 61539..61664 | + | 126 | Protein_68 | hypothetical protein | - |
| JRC41_RS21990 (JRC41_21990) | 61647..62372 | + | 726 | WP_244256308.1 | DUF551 domain-containing protein | - |
| JRC41_RS21995 (JRC41_21995) | 62369..62632 | + | 264 | WP_208631219.1 | eaa protein | - |
| JRC41_RS22000 (JRC41_22000) | 62715..62948 | + | 234 | WP_000517420.1 | hypothetical protein | - |
| JRC41_RS22550 | 62998..63120 | + | 123 | WP_279631862.1 | hypothetical protein | - |
| JRC41_RS22005 (JRC41_22005) | 63127..63420 | + | 294 | WP_208631220.1 | hypothetical protein | - |
| JRC41_RS22010 (JRC41_22010) | 63420..63596 | + | 177 | WP_208631221.1 | hypothetical protein | - |
| JRC41_RS22015 (JRC41_22015) | 63811..64470 | + | 660 | WP_208631222.1 | hypothetical protein | - |
| JRC41_RS22020 (JRC41_22020) | 64601..64996 | - | 396 | WP_208631223.1 | hypothetical protein | - |
| JRC41_RS22025 (JRC41_22025) | 65037..65243 | - | 207 | WP_208631224.1 | hypothetical protein | - |
| JRC41_RS22030 (JRC41_22030) | 65426..66001 | - | 576 | WP_208631225.1 | DNA-binding protein | - |
| JRC41_RS22035 (JRC41_22035) | 66224..66445 | + | 222 | WP_001190714.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| JRC41_RS22040 (JRC41_22040) | 66445..66825 | + | 381 | WP_208631226.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| JRC41_RS22045 (JRC41_22045) | 66845..67120 | + | 276 | WP_208631227.1 | hypothetical protein | - |
| JRC41_RS22050 (JRC41_22050) | 67125..67304 | + | 180 | WP_000113019.1 | hypothetical protein | - |
| JRC41_RS22055 (JRC41_22055) | 67341..68384 | + | 1044 | WP_208631272.1 | DUF968 domain-containing protein | - |
| JRC41_RS22060 (JRC41_22060) | 68473..68925 | + | 453 | WP_001312282.1 | late promoter-activating protein (Gp10) | - |
| JRC41_RS22065 (JRC41_22065) | 69012..70205 | + | 1194 | WP_208631228.1 | terminase | - |
| JRC41_RS22070 (JRC41_22070) | 70205..71689 | + | 1485 | WP_208631229.1 | terminase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | pefD | 1..96586 | 96586 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13643.46 Da Isoelectric Point: 5.6513
>T193729 WP_208631226.1 NZ_CP070291:66445-66825 [Escherichia albertii]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVVYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEIAVSSVAEKLRELYGSKT
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVVYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEIAVSSVAEKLRELYGSKT
Download Length: 381 bp
>T193729 NZ_CP093188:886456-886818 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTGAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTGAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8123.06 Da Isoelectric Point: 4.7708
>AT193729 WP_001190714.1 NZ_CP070291:66224-66445 [Escherichia albertii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGRESAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGRESAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
Download Length: 222 bp
>AT193729 NZ_CP093188:886289-886459 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTTCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTTCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|