Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3315877..3316495 Replicon chromosome
Accession NZ_CP070290
Organism Escherichia albertii strain Sample 167

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag JRC41_RS15890 Protein ID WP_001280991.1
Coordinates 3316277..3316495 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag JRC41_RS15885 Protein ID WP_000344798.1
Coordinates 3315877..3316251 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC41_RS15875 (3310957) 3310957..3312150 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JRC41_RS15880 (3312173) 3312173..3315322 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
JRC41_RS15885 (3315877) 3315877..3316251 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
JRC41_RS15890 (3316277) 3316277..3316495 + 219 WP_001280991.1 HHA domain-containing protein Toxin
JRC41_RS15895 (3316672) 3316672..3317229 + 558 WP_000093561.1 maltose O-acetyltransferase -
JRC41_RS15900 (3317337) 3317337..3317807 + 471 WP_059224581.1 YlaC family protein -
JRC41_RS15905 (3317971) 3317971..3319521 + 1551 WP_001260378.1 EAL domain-containing protein -
JRC41_RS15910 (3319559) 3319559..3319912 - 354 WP_000878151.1 DUF1428 family protein -
JRC41_RS15920 (3320293) 3320293..3320604 + 312 WP_000409915.1 MGMT family protein -
JRC41_RS15925 (3320634) 3320634..3321206 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T193721 WP_001280991.1 NZ_CP070290:3316277-3316495 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T193721 NZ_CP093181:c1750948-1750553 [Staphylococcus epidermidis]
ATGCAAAGCACTAAATATTTAACTGAAAAACAAGTGATTGCCATTAATGTAAAAGCAATACAAGATTTCTCACCAAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAAGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTCGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCAGCTTTTATATATAGAAATATAGCTCAAAAGCACGCATTCCATAATGCGAATAAAAGA
ACAGCTTTTACATCTATGGTAATATTTTTGAAGTTAAATAGTATTAATTTTGAATGCACTCAAGATGAAGCGGTTCAGTT
TACTTTAAGAGTAGTAAACGACAAAAATCTTACTCTTGAGGGAATTGAGACATGGATCAAGAGGCATTGTAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT193721 WP_000344798.1 NZ_CP070290:3315877-3316251 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp

>AT193721 NZ_CP093181:c1751178-1750948 [Staphylococcus epidermidis]
ATGATTACTACAAGAAAACTAAGAAAAGCTGGTAATAGTTCAGTTGTTTCTGTACCGACAGAAGTGATCGCAGCACTCGG
AATATCAAATGGTGATAATCTTAAATTTAATGTAAAAGATAATAAAGTAACCATCGAAAAGGAGGTAAGAGAGGACGAGG
AGTTTTTTAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTTTAAAAAGGATGGTTGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References