Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2289450..2290054 Replicon chromosome
Accession NZ_CP070290
Organism Escherichia albertii strain Sample 167

Toxin (Protein)


Gene name doc Uniprot ID B1EM00
Locus tag JRC41_RS11035 Protein ID WP_000638401.1
Coordinates 2289668..2290054 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag JRC41_RS11030 Protein ID WP_001195490.1
Coordinates 2289450..2289671 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC41_RS11015 (2285700) 2285700..2287151 + 1452 WP_059238165.1 tagaturonate reductase -
JRC41_RS11020 (2287356) 2287356..2288270 + 915 WP_024164792.1 bestrophin family protein -
JRC41_RS11025 (2288274) 2288274..2289032 - 759 WP_044709411.1 trans-aconitate 2-methyltransferase -
JRC41_RS11030 (2289450) 2289450..2289671 + 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JRC41_RS11035 (2289668) 2289668..2290054 + 387 WP_000638401.1 type II toxin-antitoxin system death-on-curing family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14505.49 Da        Isoelectric Point: 8.0833

>T193719 WP_000638401.1 NZ_CP070290:2289668-2290054 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

>T193719 NZ_CP093181:c665559-665098 [Staphylococcus epidermidis]
GTGGGGAAATATGAGGATATGTTAATTGAACATGACTATATTGAAGTCATTGAATGTGATAACTTACCTAAAAGGTTATC
TGGCTTGTGGCTTGGAGATATGATTTTAATTAATCGTAACTTACCTATTACTTCCAAACTTGAAACACTTGCAGAGGAAC
TCGCTCATAACGAACTTACATATGGAAATATAGTTGATCAAAGTAGTTTTAATCATAGAAAATTTGAAGGTTATGCACGT
AGGTTAGCCTATGAAAAGTTAGTCCCTCTTAAAGATATTGTAAAAGCATTTTTGCAAGGCATTCATGACTTGTATGAACT
TGCTAATTTTTTTGAGGTTACAGAAGGTTTTGTCCAACAAAGTATTGCACATTATAAACAAAAATATGGCTTAACAACTC
GATGTGGTGATTATGTTATAGCATTTGAACCTTTAAGAGTTTTTGAGTACAAAGAAATATAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT193719 WP_001195490.1 NZ_CP070290:2289450-2289671 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp

>AT193719 NZ_CP093181:c665901-665572 [Staphylococcus epidermidis]
ATGAGAAATAATGATGAAATAATCACAATAATTAAATCAGCTATGAAAGAACAAGATATGTCACTTAGTGAATTAGCTCG
TCGTGTAGGAGTTGCTAAATCTGCTGTATCACGTTATTTAAACTTAACTAGAGAATTTCCGTTAAATCGTACAGAAGATT
TTGCAAAAGCACTTAGTATCAGTACAGAATACTTACTTGGTTTTGACAAAAGTGAACAACAAGATGAACAACCACAACAT
CGTGCAGCACATCTTGATGGTGATTTAACTGACGAAGAATGGCAAGAAATTCTTGATTACGCTGAATACATAAGAAGTAA
AAGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T5VDW2

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References