Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 884362..885013 Replicon chromosome
Accession NZ_CP070290
Organism Escherichia albertii strain Sample 167

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag JRC41_RS04240 Protein ID WP_000244763.1
Coordinates 884609..885013 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JRC41_RS04235 Protein ID WP_000354046.1
Coordinates 884362..884628 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC41_RS04205 (879371) 879371..880264 + 894 WP_107192338.1 transporter -
JRC41_RS04210 (880312) 880312..881745 - 1434 WP_208631116.1 6-phospho-beta-glucosidase BglA -
JRC41_RS04215 (881790) 881790..882101 + 312 WP_137649989.1 N(4)-acetylcytidine aminohydrolase -
JRC41_RS04220 (882269) 882269..882928 + 660 WP_000250281.1 hemolysin III family protein -
JRC41_RS04225 (883130) 883130..884110 - 981 WP_000886056.1 tRNA-modifying protein YgfZ -
JRC41_RS04230 (884142) 884142..884372 + 231 WP_000181267.1 hypothetical protein -
JRC41_RS04235 (884362) 884362..884628 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JRC41_RS04240 (884609) 884609..885013 + 405 WP_000244763.1 protein YgfX Toxin
JRC41_RS04245 (885052) 885052..885573 - 522 WP_085456580.1 flavodoxin FldB -
JRC41_RS04250 (885685) 885685..886581 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JRC41_RS04255 (886606) 886606..887316 + 711 WP_000748105.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JRC41_RS04260 (887322) 887322..889055 + 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T193708 WP_000244763.1 NZ_CP070290:884609-885013 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T193708 NZ_CP093173:879908-880270 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT193708 WP_000354046.1 NZ_CP070290:884362-884628 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT193708 NZ_CP093173:879741-879911 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References