Detailed information of TA system TA193702

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 142261..142873
• Replicon: chromosome
• Accession: NZ_CP070290
• Organism: Escherichia albertii strain Sample 167

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: U9YXE2
• Locus tag: JRC41_RS00620
• Protein ID: WP_000833473.1
• Coordinates: 142261..142446 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JRC41_RS00625
• Protein ID: WP_059235556.1
• Coordinates: 142463..142873 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC41_RS00605 (137725)	137725..139020	+	1296	WP_059235552.1	Fic family protein	-
JRC41_RS00610 (139128)	139128..140666	+	1539	WP_002460288.1	aldehyde dehydrogenase AldB	-
JRC41_RS00615 (140707)	140707..141786	-	1080	WP_025238097.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
JRC41_RS00620 (142261)	142261..142446	+	186	WP_000833473.1	type II toxin-antitoxin system HicA family toxin	Toxin
JRC41_RS00625 (142463)	142463..142873	+	411	WP_059235556.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JRC41_RS00630 (142945)	142945..144909	-	1965	WP_025238098.1	glycoside hydrolase family 127 protein	-
JRC41_RS00635 (144920)	144920..146320	-	1401	WP_025238099.1	MFS transporter	-
JRC41_RS00640 (146546)	146546..147361	+	816	WP_059242247.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6800.89 Da
• Isoelectric Point: 11.7053

>T193702 WP_000833473.1 NZ_CP070290:142261-142446 [Escherichia albertii]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Nucleotide

• Length: 186 bp

>T193702 NZ_CP093165:1937002-1937190 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 15193.10 Da
• Isoelectric Point: 4.5486

>AT193702 WP_059235556.1 NZ_CP070290:142463-142873 [Escherichia albertii]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQVEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Nucleotide

• Length: 411 bp

>AT193702 NZ_CP093165:1936720-1936977 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAATTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA

Structures

Toxin

• AlphaFold DB: U9YXE2