Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 83691..84292 Replicon plasmid pESA118_2
Accession NZ_CP070289
Organism Escherichia albertii strain Sample 168

Toxin (Protein)


Gene name doc Uniprot ID F0JYA5
Locus tag JRC45_RS24280 Protein ID WP_001216044.1
Coordinates 83912..84292 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag JRC45_RS24275 Protein ID WP_001190712.1
Coordinates 83691..83912 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC45_RS24745 78937..79116 + 180 Protein_96 hypothetical protein -
JRC45_RS24235 (JRC45_24235) 79466..79759 + 294 WP_039022009.1 hypothetical protein -
JRC45_RS24240 (JRC45_24240) 79759..79923 + 165 WP_152950163.1 hypothetical protein -
JRC45_RS24245 (JRC45_24245) 79990..80364 + 375 WP_039022008.1 hypothetical protein -
JRC45_RS24250 (JRC45_24250) 80346..81095 + 750 WP_171841598.1 hypothetical protein -
JRC45_RS24255 (JRC45_24255) 81165..81431 + 267 WP_223671585.1 hypothetical protein -
JRC45_RS24260 (JRC45_24260) 82221..82472 + 252 WP_039022007.1 DNA polymerase III subunit theta -
JRC45_RS24265 (JRC45_24265) 82479..83054 - 576 WP_039022006.1 hypothetical protein -
JRC45_RS24270 (JRC45_24270) 83229..83618 + 390 WP_000506730.1 S24 family peptidase -
JRC45_RS24275 (JRC45_24275) 83691..83912 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JRC45_RS24280 (JRC45_24280) 83912..84292 + 381 WP_001216044.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
JRC45_RS24285 (JRC45_24285) 84297..84476 + 180 WP_039022005.1 hypothetical protein -
JRC45_RS24290 (JRC45_24290) 84504..85373 + 870 Protein_108 DUF968 domain-containing protein -
JRC45_RS24910 85390..85515 + 126 WP_257233066.1 hypothetical protein -
JRC45_RS24295 (JRC45_24295) 85548..86399 - 852 WP_000611653.1 phage repressor protein C1 -
JRC45_RS24300 (JRC45_24300) 86510..86719 - 210 WP_000874154.1 hypothetical protein -
JRC45_RS24305 (JRC45_24305) 86910..87607 + 698 WP_223678491.1 IS1-like element IS1B family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid qnrS2 / tet(A) - 1..94500 94500


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13544.28 Da        Isoelectric Point: 5.6343

>T193701 WP_001216044.1 NZ_CP070289:83912-84292 [Escherichia albertii]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVAATLRRLYGSAE

Download         Length: 381 bp

>T193701 NZ_CP093165:975966-976145 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT193701 WP_001190712.1 NZ_CP070289:83691-83912 [Escherichia albertii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT193701 NZ_CP093165:975343-975942 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6Y6HMN5

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References