Detailed information of TA system TA193700

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 17509..18044
• Replicon: plasmid pESA118_2
• Accession: NZ_CP070289
• Organism: Escherichia albertii strain Sample 168

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JRC45_RS23840
• Protein ID: WP_032206513.1
• Coordinates: 17757..18044 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: T1PXV2
• Locus tag: JRC45_RS23835
• Protein ID: WP_001139206.1
• Coordinates: 17509..17760 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRC45_RS23830 (JRC45_23830)	12959..16849	-	3891	WP_223667647.1	helicase-related protein	-
JRC45_RS23835 (JRC45_23835)	17509..17760	+	252	WP_001139206.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JRC45_RS23840 (JRC45_23840)	17757..18044	+	288	WP_032206513.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JRC45_RS24725	18412..18525	-	114	Protein_20	alkaline phosphatase	-
JRC45_RS23850 (JRC45_23850)	18524..18729	+	206	Protein_21	hypothetical protein	-
JRC45_RS23855 (JRC45_23855)	18904..22437	-	3534	WP_065311112.1	autotransporter outer membrane beta-barrel domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	qnrS2 / tet(A)	-	1..94500	94500

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11130.20 Da
• Isoelectric Point: 10.5833

>T193700 WP_032206513.1 NZ_CP070289:17757-18044 [Escherichia albertii]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQIIDDMLIIAVVAVGK
RERSNVYHLASERMK

Nucleotide

• Length: 288 bp

>T193700 NZ_CP093165:828823-829185 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9171.39 Da
• Isoelectric Point: 4.0927

>AT193700 WP_001139206.1 NZ_CP070289:17509-17760 [Escherichia albertii]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Nucleotide

• Length: 252 bp

>AT193700 NZ_CP093165:828656-828826 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: T1PXV2