Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3527193..3527811 Replicon chromosome
Accession NZ_CP070287
Organism Escherichia albertii strain Sample 168

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag JRC45_RS17525 Protein ID WP_001280991.1
Coordinates 3527593..3527811 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag JRC45_RS17520 Protein ID WP_000344798.1
Coordinates 3527193..3527567 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC45_RS17510 (3522273) 3522273..3523466 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JRC45_RS17515 (3523489) 3523489..3526638 + 3150 WP_204628715.1 multidrug efflux RND transporter permease subunit AcrB -
JRC45_RS17520 (3527193) 3527193..3527567 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
JRC45_RS17525 (3527593) 3527593..3527811 + 219 WP_001280991.1 HHA domain-containing protein Toxin
JRC45_RS17530 (3527988) 3527988..3528545 + 558 WP_204628716.1 maltose O-acetyltransferase -
JRC45_RS17535 (3528653) 3528653..3529123 + 471 WP_204628717.1 YlaC family protein -
JRC45_RS17540 (3529287) 3529287..3530837 + 1551 WP_001260378.1 EAL domain-containing protein -
JRC45_RS17545 (3530875) 3530875..3531228 - 354 WP_000878151.1 DUF1428 family protein -
JRC45_RS17555 (3531609) 3531609..3531920 + 312 WP_000409915.1 MGMT family protein -
JRC45_RS17560 (3531950) 3531950..3532522 - 573 WP_059216668.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T193690 WP_001280991.1 NZ_CP070287:3527593-3527811 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T193690 NZ_CP093154:c1342363-1342037 [Enterobacter asburiae]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCAGCGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGGC
GCGTTTGCTGGAACAGCACTACGGTCTGACAATAAACGACACCCCATTCAGCGATGAAGTTGTTATACAGCAACATATCG
ATGCCGGTATCACCCTGTCAGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTCCGTATCGACAGGAAGGGATTT
CGCTGGCAGGAACAATCCCCTTACCTTCGGGCTGTCGATATTCTGAGGGCAAGACAGGCAATAGGTCTTTTACGAGGATC
TCATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT193690 WP_000344798.1 NZ_CP070287:3527193-3527567 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp

>AT193690 NZ_CP093154:c1342701-1342384 [Enterobacter asburiae]
ATGACCCACATCATCTGGGGCCTGCAGCGGGCTATCACGCCGCGCCTGGGAGCCCGTCTGGTACAGGAGGGCAACCGGCT
GCACTACCTGGCTGACCGGGCCAGCATCACCGGTATGTTCAGTGACGCCGAATGCCGGAAGCTGGATGACACATTCCCAC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCAACATGCCCACTGCGTCACCCTGTACCAC
AACGGTTTTACCTGTGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References