Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 11161..11708 Replicon plasmid pESA134_2
Accession NZ_CP070286
Organism Escherichia albertii strain Sample 169

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag JRC46_RS24085 Protein ID WP_001384452.1
Coordinates 11430..11708 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag JRC46_RS24080 Protein ID WP_204620402.1
Coordinates 11161..11430 (+) Length 90 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC46_RS24050 (6920) 6920..7519 + 600 WP_204620398.1 PIN domain-containing protein -
- (8124) 8124..8185 - 62 NuclAT_1 - -
- (8124) 8124..8185 - 62 NuclAT_1 - -
- (8124) 8124..8185 - 62 NuclAT_1 - -
- (8124) 8124..8185 - 62 NuclAT_1 - -
JRC46_RS24055 (8229) 8229..8378 + 150 WP_244259636.1 Hok/Gef family protein -
JRC46_RS24060 (8662) 8662..8919 + 258 WP_000083834.1 replication regulatory protein RepA -
JRC46_RS25565 (9154) 9154..9228 + 75 WP_064763977.1 RepA leader peptide Tap -
JRC46_RS24070 (9221) 9221..10243 + 1023 WP_204620400.1 plasmid replication initiator RepA -
JRC46_RS24075 (10948) 10948..11106 + 159 WP_204620401.1 hypothetical protein -
JRC46_RS24080 (11161) 11161..11430 + 270 WP_204620402.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
JRC46_RS24085 (11430) 11430..11708 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
JRC46_RS24090 (11736) 11736..11798 + 63 Protein_13 3'-5' exonuclease -
JRC46_RS24095 (11887) 11887..12171 + 285 WP_204620403.1 ribbon-helix-helix domain-containing protein -
JRC46_RS24100 (12171) 12171..12431 + 261 Protein_15 type II toxin-antitoxin system RelE/ParE family toxin -
JRC46_RS24105 (12527) 12527..12784 + 258 WP_204620446.1 hypothetical protein -
JRC46_RS24110 (12786) 12786..13481 + 696 WP_204678096.1 hypothetical protein -
JRC46_RS24115 (13485) 13485..13946 + 462 WP_204678098.1 hypothetical protein -
JRC46_RS24120 (14211) 14211..14749 - 539 Protein_19 transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - espC / espC 1..176494 176494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T193667 WP_001384452.1 NZ_CP070286:11430-11708 [Escherichia albertii]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T193667 NZ_CP093068:c4374622-4374245 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGGCCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10265.63 Da        Isoelectric Point: 8.8736

>AT193667 WP_204620402.1 NZ_CP070286:11161-11430 [Escherichia albertii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHNMVESSAAAWRD
EMSRKIAGK

Download         Length: 270 bp

>AT193667 NZ_CP093068:c4375080-4374712 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829CL36


Antitoxin

Source ID Structure

References